4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉

• 常用名: 4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉
• 英文名: 4-(3-bromoanilino)-6,7-diethoxyquinazoline
• CAS号: 171745-13-4
• 分子量: 388.26
• 密度: 1.4±0.1 g/cm3
• 沸点: 492.6±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₈BrN₃O₂
• 熔点: N/A
• 闪点: 251.7±28.7 °C

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉用途

EGFR-IN-80(化合物 30)是一种 EGFR 抑制剂,pIC50 为 10.6。

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉名称

• 中文名: 4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉
• 英文名: N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉生物活性

• 描述: EGFR-IN-80(化合物 30)是一种 EGFR 抑制剂,pIC50 为 10.6。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  EGFR:10.6 (pIC50)

• 参考文献:

  [1]. Farhan Ahmad Pasha, et al. In silico QSAR studies of anilinoquinolines as EGFR inhibitors. J Mol Model. 2010 Feb;16(2):263-77.

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 492.6±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₈BrN₃O₂
• 分子量: 388.26
• 闪点: 251.7±28.7 °C
• 精确质量: 387.058228
• PSA: 56.27000
• LogP: 5.14
• InChIKey: YXOXHAUUTIOBDA-UHFFFAOYSA-N
• SMILES: CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.652

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉安全信息

4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉靶点实验

查看更多实验

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

实验名称：Delta TM value showing the stabilisation of CLK2 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3430803

实验名称：Delta TM value showing the stabilisation of CLK3 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK3 External Id：CHEMBL3430804

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4-[(3-溴苯基)氨基]-6,7-二乙氧基喹唑啉英文别名

• compound 56
• N-(3-Bromophenyl)-6,7-diethoxyquinazolin-4-amine
• 4-(3'-bromoanilino)-6,7-diethoxyquinazoline
• 4-(3-bromoanilino)-6,7-diethoxyquinazoline
• N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine
• 4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline
• (3-Bromophenyl)-(6,7-diethoxyquinazolin-4-yl)-amine
• YXOXHAUUTIOBDA-UHFFFAOYSA