Methyl oleanonate

• 常用名: Methyl oleanonate
• 英文名: Methyl oleanonate
• CAS号: 1721-58-0
• 分子量: 468.71100
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₄₈O₃
• 熔点: N/A
• 闪点: N/A

Methyl oleanonate用途

Methyl oleanonate 是从 Pistacia 中分离得到的三萜类 PPARγ 激动剂。Methyl oleanonate 是齐墩果酸衍生物,具有抗癌作用。

Methyl oleanonate名称

• 英文名: 3-Oxo-olean-12-en-28-oic acid methyl ester

Methyl oleanonate生物活性

• 描述: Methyl oleanonate 是从 Pistacia 中分离得到的三萜类 PPARγ 激动剂。Methyl oleanonate 是齐墩果酸衍生物,具有抗癌作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
• 靶点实验:

  PPARγ

• 参考文献:

  [1]. Rasmus K Petersen, et al. Pharmacophore-driven identification of PPARγ agonists from natural sources. J Comput Aided Mol Des. 2011 Feb;25(2):107-16.

  [2]. Barbara Bednarczyk-Cwynar, et al. Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines. Org Biomol Chem. 2012 Mar 21;10(11):2201-5

Methyl oleanonate物理化学性质

• 分子式: C₃₁H₄₈O₃
• 分子量: 468.71100
• 精确质量: 468.36000
• PSA: 43.37000
• LogP: 7.53020
• InChIKey: PPMUFCXCVKVCSV-VNNAKPRGSA-N
• SMILES: COC(=O)C12CCC(C)(C)CC1C1=CCC3C4(C)CCC(=O)C(C)(C)C4CCC3(C)C1(C)CC2

Methyl oleanonate靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3370453

实验名称：Inhibition of recombinant PTP1B expressed in Escherichia coli BL21 up to 5 ug/ml afte... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL1635808

实验名称：Inhibition of recombinant PTP1B expressed in Escherichia coli BL21 after 30 mins by s... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL1635809

实验名称：Cytotoxicity against Homo sapiens (human) SR cells assessed as cellular growth at 10'... 来源：ChEMBL 靶标：SR External Id：CHEMBL3062012

实验名称：Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated f... 来源：ChEMBL 靶标：J774.A1 External Id：CHEMBL3370212

实验名称：Cytotoxicity against Homo sapiens (human) PC3 cells assessed as cellular growth at 10... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL3062013

实验名称：Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3370452

实验名称：Inhibition of TNF-alpha stimulated NF-kappaB (unknown origin) expressed in mouse NIH/... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4193073

实验名称：Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL3117224

实验名称：Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL3117225

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Methyl oleanonate英文别名

• 3-Oxoolean-12-en-28-oic acid methyl ester
• Methyl oleanonate