BMS-986188

• 常用名: BMS-986188
• 英文名: BMS-986188
• CAS号: 1776115-10-6
• 分子量: 535.47
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₁BrO₄
• 熔点: N/A
• 闪点: N/A

BMS-986188用途

BMS-986188是δ-阿片受体的选择性正变构调节剂,EC50为0.05μM【1】。

BMS-986188名称

• 英文名: BMS 986188

BMS-986188生物活性

• 描述: BMS-986188是δ-阿片受体的选择性正变构调节剂,EC50为0.05μM【1】。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Burford NT, et al. Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J Med Chem. 2015 May 28;58(10):4220-9.

BMS-986188物理化学性质

• 分子式: C₃₀H₃₁BrO₄
• 分子量: 535.47
• InChIKey: BBCHHZHONQIODT-UHFFFAOYSA-N
• SMILES: CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(OCc2ccccc2Br)cc1

BMS-986188靶点实验

查看更多实验

实验名称：Inhibition of human DOR expressed in CHO cells assessed as reduction in Leu-enkephali... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL5120386

实验名称：Inhibition of human DOR expressed in CHO cells assessed as reduction in Leu-enkephali... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL5120387

实验名称：Agonist activity at human delta opioid receptor-1 expressed in CHO cells after 90 min... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL3428520

实验名称：Solubility of the compound in phosphate buffered saline assessed as particulate matte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3429364

实验名称：Solubility of the compound in HBSS/HEPES/FBS assessed as particulate matter formation... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3429365

实验名称：Positive allosteric modulation of human mu opioid receptor-1 expressed in CHO cells a... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL3428523

实验名称：Binding affinity human DOR expressed in CHO cells assessed as reduction in phosphoryl... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL5120383

实验名称：Selectivity ratio of EC50 for human mu opioid receptor-1 expressed in CHO cells to EC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3428524

实验名称：Inhibition of human DOR expressed in CHO cells assessed as reduction in Leu-enkephali... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL5120384

实验名称：Inhibition of human DOR expressed in CHO cells assessed as reduction in Leu-enkephali... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL5120385

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