ARRY 520 trifluoroacetate

• 常用名: ARRY 520 trifluoroacetate
• 英文名: ARRY 520 trifluoroacetate
• CAS号: 1781834-99-8
• 分子量: 534.499
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃F₅N₄O₄S
• 熔点: N/A
• 闪点: N/A

ARRY 520 trifluoroacetate用途

Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents.

ARRY 520 trifluoroacetate名称

• 英文名: ARRY-520

ARRY 520 trifluoroacetate物理化学性质

• 分子式: C₂₂H₂₃F₅N₄O₄S
• 分子量: 534.499
• 精确质量: 534.135986

ARRY 520 trifluoroacetate英文别名

• Acetic acid, 2,2,2-trifluoro-, compd. with (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide (1:1)
• (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate (1:1)
• ARRY-520