TA-02

• 常用名: TA-02
• 英文名: TA-02
• CAS号: 1784751-19-4
• 分子量: 333.334
• 密度: 1.3±0.1 g/cm3
• 沸点: 515.7±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₃F₂N₃
• 熔点: N/A
• 闪点: 265.7±30.1 °C

TA-02用途

TA-02是一种 p38 MAPK 抑制剂, IC50 值为20 nM 。

TA-02名称

• 中文名: TA-02
• 英文名: TA-02

TA-02生物活性

• 描述: TA-02是一种 p38 MAPK 抑制剂, IC50 值为20 nM 。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

  [2]. Filip LACO, et al. 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis. WO 2015119579 A1.

TA-02物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 515.7±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₃F₂N₃
• 分子量: 333.334
• 闪点: 265.7±30.1 °C
• 精确质量: 333.107758
• LogP: 4.99
• InChIKey: QIFJOFNVIVQRNJ-UHFFFAOYSA-N
• SMILES: Fc1ccc(-c2nc(-c3ccccc3F)[nH]c2-c2ccncc2)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.619
• 储存条件: -20°C，密闭，干燥

TA-02靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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TA-02英文别名

• 4-[2-(2-Fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine