CFM-2

• 常用名: CFM-2
• 英文名: CFM 2
• CAS号: 178616-26-7
• 分子量: 311.33500
• 密度: 1.32g/cm3
• 沸点: N/A
• 分子式: C₁₇H₁₇N₃O₃
• 熔点: N/A
• 闪点: N/A

CFM-2用途

CFM-2是AMPAR选择非竞争性抑制剂。

CFM-2名称

• 中文名: 1-(4-氨基苯基)-3,5-二氢-7,8-二甲氧基-4H-2,3-苯并二氮杂-4-酮
• 英文名: 1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one

CFM-2生物活性

• 描述: CFM-2是AMPAR选择非竞争性抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. De Sarro G, et al. Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats. Eur J Pharmacol. 1999 Mar 5;368(2-3):149-59.

  [2]. Rizzo M, et al. Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 1999 Aug 20;731(2):207-15.

  [3]. Stepulak A, et al. AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth. Cancer Biol Ther. 2007 Dec;6(12):1908-15.

  [4]. Park JS, et al. Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain. 2008 Dec 30;4:67.

CFM-2物理化学性质

• 密度: 1.32g/cm3
• 分子式: C₁₇H₁₇N₃O₃
• 分子量: 311.33500
• 精确质量: 311.12700
• PSA: 85.94000
• LogP: 2.05630
• InChIKey: MJKADKZSYQWGLL-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OC)C(c1ccc(N)cc1)=NNC(=O)C2
• 折射率: 1.637
• 储存条件: 2-8℃

CFM-2靶点实验

查看更多实验

实验名称：In vitro inhibition of AMPA activated current in xenopus oocytes expressing rat cereb... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL781262

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：In vivo anticonvulsant activity was measured as median effective dose required to pre... 来源：ChEMBL 靶标：Glutamate receptor 4 External Id：CHEMBL716221

实验名称：Anticonvulsant activity against Audiogenic seizures in DBA/2 mice was observed in clo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL662852

实验名称：Anticonvulsant activity against Audiogenic seizures in DBA/2 mice was observed in clo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL662853

实验名称：Anticonvulsant activity against Audiogenic seizures in DBA/2 mice was observed in ton... 来源：ChEMBL 靶标：N/A External Id：CHEMBL662854

实验名称：Anticonvulsant activity was determined when tested at 15 min from intraperitoneal adm... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL842180

实验名称：Anticonvulsant activity against AMPA-induced seizures in DBA/2 mice was observed in c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL663223

实验名称：Anticonvulsant activity against Audiogenic seizures in DBA/2 mice was observed in ton... 来源：ChEMBL 靶标：N/A External Id：CHEMBL660295

实验名称：Anticonvulsant activity against AMPA-induced seizures in DBA/2 mice was observed in t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL663224

共88条，当前第1页，共9页

1

2

3

4

5

CFM-2英文别名

• Eeyarestatin I
• Tocris-1082
• CFM-2