NLRP3/AIM2-IN-3

• 常用名: NLRP3/AIM2-IN-3
• 英文名: NLRP3/AIM2-IN-3
• CAS号: 1787787-60-3
• 分子量: 266.29
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₄N₂O₂
• 熔点: N/A
• 闪点: N/A

NLRP3/AIM2-IN-3用途

NLRP3/AIM2-IN-3是一种独特的分子,可抑制NLRP3和AIM2炎症体的激活,并具有物种差异。其IC₅₀值为0.077±0.008μM

NLRP3/AIM2-IN-3名称

• 英文名: NLRP3/AIM2-IN-3

NLRP3/AIM2-IN-3生物活性

• 描述: NLRP3/AIM2-IN-3是一种独特的分子,可抑制NLRP3和AIM2炎症体的激活,并具有物种差异。其IC₅₀值为0.077±0.008μM
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  inhibitory activity against NLRP3 and AIM2:0.077±0.00 μM (IC50)

• 参考文献:

  [1]. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.

NLRP3/AIM2-IN-3物理化学性质

• 分子式: C₁₆H₁₄N₂O₂
• 分子量: 266.29
• InChIKey: UOBOMCZZCHPHBU-UHFFFAOYSA-N
• SMILES: O=C(Cc1ccc2cc[nH]c2c1)Nc1cccc(O)c1

NLRP3/AIM2-IN-3靶点实验

查看更多实验

实验名称：Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assesse... 来源：ChEMBL 靶标：NACHT, LRR and PYD domains-containing protein 3 External Id：CHEMBL5138399

实验名称：Inhibition of AIM2 inflammasome activation in LPS-primed mouse J774A.1 cells assessed... 来源：ChEMBL 靶标：Interferon-inducible protein AIM2 External Id：CHEMBL5138400

实验名称：Inhibition of AIM2 inflammasome activation in LPS-primed mouse J774A.1 cells assessed... 来源：ChEMBL 靶标：Interferon-inducible protein AIM2 External Id：CHEMBL5138401

实验名称：Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assesse... 来源：ChEMBL 靶标：NACHT, LRR and PYD domains-containing protein 3 External Id：CHEMBL5138402

实验名称：Inhibition of NLRC4 inflammasome activation in LPS-primed human THP-1 cells infected ... 来源：ChEMBL 靶标：NLR family CARD domain-containing protein 4 External Id：CHEMBL5138395

实验名称：Inhibition of NLRC4 inflammasome activation in LPS-primed human THP-1 cells infected ... 来源：ChEMBL 靶标：NLR family CARD domain-containing protein 4 External Id：CHEMBL5138396

实验名称：Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assesse... 来源：ChEMBL 靶标：NACHT, LRR and PYD domains-containing protein 3 External Id：CHEMBL5138397

实验名称：Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assesse... 来源：ChEMBL 靶标：NACHT, LRR and PYD domains-containing protein 3 External Id：CHEMBL5138398

实验名称：Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed a... 来源：ChEMBL 靶标：Interferon-inducible protein AIM2 External Id：CHEMBL5138391

实验名称：Inhibition of AIM2 inflammasome activation in LPS-primed human THP-1 cells assessed a... 来源：ChEMBL 靶标：Interferon-inducible protein AIM2 External Id：CHEMBL5138392

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