4-[(S)-[(2S,5R)-2,5-二甲基-4-(2-丙烯-1-基)-1-哌嗪基]苯基甲基]-N,N-二乙基苯甲酰胺

• 常用名: 4-[(S)-[(2S,5R)-2,5-二甲基-4-(2-丙烯-1-基)-1-哌嗪基]苯基甲基]-N,N-二乙基苯甲酰胺
• 英文名: SNC 162
• CAS号: 178803-51-5
• 分子量: 419.60
• 密度: 1.027g/cm3
• 沸点: 536.4ºC at 760mmHg
• 分子式: C₂₇H₃₇N₃O
• 熔点: N/A
• 闪点: 202.4ºC

用途

SNC162是一种δ阿片受体激动剂,IC50为0.94 nM。SNC162具有抗抑郁样作用,可选择性增强芬太尼对恒河猴的抗伤害作用[1][2]。

名称

• 中文名: 4-[(S)-[(2S,5R)-2,5-二甲基-4-(2-丙烯-1-基)-1-哌嗪基]苯基甲基]-N,N-二乙基苯甲酰胺
• 英文名: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide

生物活性

• 描述: SNC162是一种δ阿片受体激动剂,IC50为0.94 nM。SNC162具有抗抑郁样作用,可选择性增强芬太尼对恒河猴的抗伤害作用[1][2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 0.94 nM (delta-opioid receptor)[1]

• 参考文献:

  [1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81.

  [2]. Banks ML, et al. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12.

物理化学性质

• 密度: 1.027g/cm3
• 沸点: 536.4ºC at 760mmHg
• 分子式: C₂₇H₃₇N₃O
• 分子量: 419.60
• 闪点: 202.4ºC
• 精确质量: 419.29400
• PSA: 26.79000
• LogP: 4.71440
• InChIKey: WGIDFDFAOQVAHY-UFPGJGBJSA-N
• SMILES: C=CCN1CC(C)N(C(c2ccccc2)c2ccc(C(=O)N(CC)CC)cc2)CC1C
• 蒸汽压: 1.4E-11mmHg at 25°C
• 折射率: 1.549

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL755213

实验名称：Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 1... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL857686

实验名称：IC50 ratio on Mu receptor of GPI to the delta receptor MVD 来源：ChEMBL 靶标：N/A External Id：CHEMBL849109

实验名称：qHTS for inhibitors of Vif-A3G interactions: Validation 来源：NCGC 靶标：DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] External Id：VIFG001

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea... 来源：Broad Institute 靶标：histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] External Id：2125-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of binding or entry into cells for Marburg Virus 来源：NCGC 靶标：gene 4 small orf - Marburg virus External Id：VSVM-OFFLINE

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英文别名

• snc 162