PROTAC RIPK degrader-2

• 常用名: PROTAC RIPK degrader-2
• 英文名: PROTAC RIPK degrader-2
• CAS号: 1801547-16-9
• 分子量: 1060.31
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₂H₆₅N₇O₁₁S₃
• 熔点: N/A
• 闪点: N/A

PROTAC RIPK degrader-2用途

PROTAC RIPK degrader-2 是一种非肽性PROTAC,它以丝氨酸苏氨酸激酶 RIPK2 为靶点,对 RIPK2 的降解具有高度选择性。

PROTAC RIPK degrader-2名称

• 英文名: PROTAC RIPK degrader-2

PROTAC RIPK degrader-2生物活性

• 描述: PROTAC RIPK degrader-2 是一种非肽性PROTAC,它以丝氨酸苏氨酸激酶 RIPK2 为靶点,对 RIPK2 的降解具有高度选择性。
• 相关类别:
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 参考文献:

  [1]. Bondeson DP, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol. 2015 Aug;11(8):611-7.

PROTAC RIPK degrader-2物理化学性质

• 分子式: C₅₂H₆₅N₇O₁₁S₃
• 分子量: 1060.31
• InChIKey: RIEGJNXDHULIKM-GPPJZCFZSA-N
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)C(C)(C)C)C(C)(C)C)cc1
• 储存条件: 2-8°C

PROTAC RIPK degrader-2靶点实验

查看更多实验

实验名称：Degradation of RIPK2 (unknown origin) at more than 10 nM relative to control 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL5137719

实验名称：Protac activity against VHL/RIPK2 in human THP-1 cells assessed as induction of RIPK2... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL4349406

实验名称：PROTAC activity at VHL/RIPK2 in human THP-1 cells assessed as RIPK2 degradation by me... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL5579601

实验名称：Protac activity at VHL/RIPK2 in human THP1 cells assessed as induction of RIPK2 prote... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL4388599

共4条，当前第1页，共1页

1