ABBV-318

• 常用名: ABBV-318
• 英文名: ABBV-318
• CAS号: 1802848-94-7
• 分子量: 405.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₅F₄N₃O₂
• 熔点: N/A
• 闪点: N/A

ABBV-318用途

ABBV-318是一种有效的Nav1.7/Nav1.8阻滞剂,hNav1.7和hNav1.8的IC50分别为2.8μM和3.8μM。ABBV-318可用于疼痛研究[1]。

ABBV-318名称

• 英文名: ABBV-318

ABBV-318生物活性

• 描述: ABBV-318是一种有效的Nav1.7/Nav1.8阻滞剂,hNav1.7和hNav1.8的IC50分别为2.8μM和3.8μM。ABBV-318可用于疼痛研究[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点实验:

  hNav1.7:2.8 μM (IC50)

  hNav1.8:3.3 μM (IC50)

• 参考文献:

  [1]. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.

ABBV-318物理化学性质

• 分子式: C₂₀H₁₅F₄N₃O₂
• 分子量: 405.35
• InChIKey: FWLFRXVPNVBXGR-CQSZACIVSA-N
• SMILES: O=C(c1ccc2cc(Oc3ccc(C(F)(F)F)cn3)ccc2n1)N1CCC(F)C1

ABBV-318靶点实验

查看更多实验

实验名称：Drug concentration in plasma of monoiodoacetate-induced acute Sprague-Dawley rat mode... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147747

实验名称：Drug concentration in plasma of monoiodoacetate-induced acute Sprague-Dawley rat mode... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147748

实验名称：Drug concentration in brain of monoiodoacetate-induced acute Sprague-Dawley rat model... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147749

实验名称：Antinociceptive activity in monoiodoacetate-induced acute Sprague-Dawley rat model of... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5147739

实验名称：Antinociceptive activity in monoiodoacetate-induced subchronic Sprague-Dawley rat mod... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5147740

实验名称：Half-life in orally dosed monkey 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147734

实验名称：Volume of distribution at steady state in orally dosed monkey 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147735

实验名称：Clearance in iv dosed monkey 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147736

实验名称：Oral bioavailability in monkey 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147737

实验名称：Half-life in orally dosed dog 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147730

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