Antitumor agent-44

• 常用名: Antitumor agent-44
• 英文名: Antitumor agent-44
• CAS号: 1811548-74-9
• 分子量: 393.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₅N₃O₃
• 熔点: N/A
• 闪点: N/A

Antitumor agent-44用途

抗肿瘤剂-44(化合物5n)破坏人腺癌细胞的线粒体稳态,诱导细胞周期阻滞和凋亡。抗肿瘤剂-44(化合物5n)在肺癌细胞异种移植小鼠模型中具有良好的抗肿瘤活性[1]。

Antitumor agent-44名称

• 英文名: Antitumor agent-44

Antitumor agent-44生物活性

• 描述: 抗肿瘤剂-44(化合物5n)破坏人腺癌细胞的线粒体稳态,诱导细胞周期阻滞和凋亡。抗肿瘤剂-44(化合物5n)在肺癌细胞异种移植小鼠模型中具有良好的抗肿瘤活性[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Xiao-Xuan Su, et al. Design, synthesis, and evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma. Eur J Med Chem. 2022 Mar 15;232:114200.

Antitumor agent-44物理化学性质

• 分子式: C₂₄H₁₅N₃O₃
• 分子量: 393.39
• InChIKey: JNRQJBKOMNNIRT-UHFFFAOYSA-N
• SMILES: O=C(c1ccc2c(c1)OCO2)c1cccc2c3ccccc3n(-c3ncccn3)c12

Antitumor agent-44靶点实验

查看更多实验

实验名称：Induction of apoptosis in human A549 cells assessed as increase in P53 protein expres... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159837

实验名称：Induction of apoptosis in human A549 cells assessed as increase in Bax protein expres... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159836

实验名称：Induction of apoptosis in human A549 cells assessed as decrease in Bcl-2 protein expr... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159839

实验名称：Induction of apoptosis in human A549 cells assessed as decrease in caspase 7 protein ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159838

实验名称：Induction of apoptosis in human A549 cells assessed as increase in cleaved PARP prote... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159833

实验名称：Induction of apoptosis in human A549 cells assessed as increase in PARP protein expre... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159832

实验名称：Induction of apoptosis in human A549 cells assessed as increase in cleaved caspase 7 ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159835

实验名称：Induction of apoptosis in human A549 cells assessed as upregulation of caspase 9 prot... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159834

实验名称：Induction of apoptosis in human A549 cells assessed as necrotic cells at 1 uM incubat... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159829

实验名称：Induction of apoptosis in human A549 cells assessed as necrotic cells at 0.5 uM incub... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5159828

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