PF06650833

• 常用名: PF06650833
• 英文名: PF06650833
• CAS号: 1817626-54-2
• 分子量: 361.367
• 密度: 1.3±0.1 g/cm3
• 沸点: 621.0±55.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀FN₃O₄
• 熔点: N/A
• 闪点: 329.4±31.5 °C

PF06650833用途

PF06650833 是一种白细胞介素-1受体相关激酶-4 (IRAK4) 的抑制剂，用于效治疗类风湿性关节炎、红斑狼疮和淋巴瘤等疾病。

PF06650833名称

• 中文名: PF06650833
• 英文名: PF06650833

PF06650833生物活性

• 描述: PF06650833 是一种白细胞介素-1受体相关激酶-4 (IRAK4) 的抑制剂,用于效治疗类风湿性关节炎、红斑狼疮和淋巴瘤等疾病。
• 相关类别:
  信号通路 >> 免疫及炎症 >> IRAK
  信号通路 >> 蛋白酪氨酸激酶 >> IRAK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32.

PF06650833物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 621.0±55.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀FN₃O₄
• 分子量: 361.367
• 闪点: 329.4±31.5 °C
• 精确质量: 361.143799
• LogP: 0.19
• InChIKey: JKDGKIBAOAFRPJ-ZBINZKHDSA-N
• SMILES: CCC1C(COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)C1F
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 2-8℃

PF06650833靶点实验

查看更多实验

实验名称：Selectivity interaction (Kinase panel (Invitrogen)) EUB0000639a MAP2K1 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 1 External Id：CHEMBL5470736

实验名称：Selectivity interaction (Kinase panel (Invitrogen)) EUB0000639a MAP2K1 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 1 External Id：CHEMBL5470735

实验名称：Selectivity interaction (Kinase panel (Invitrogen)) EUB0000639a MAP2K1 来源：ChEMBL 靶标：Dual specificity mitogen-activated protein kinase kinase 1 External Id：CHEMBL5470734

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-4 External Id：CHEMBL5470733

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470732

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470731

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470730

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470729

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470728

实验名称：Selectivity interaction (ActivX KiNativ screen (kinase selectivity in THP-1 cell lysa... 来源：ChEMBL 靶标：Tyrosine-protein kinase Lyn External Id：CHEMBL5470727

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PF06650833英文别名

• 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy}-7-methoxy-6-isoquinolinecarboxamide
• S3F315JJXI