MLT-985

• 常用名: MLT-985
• 英文名: MLT-985
• CAS号: 1832576-25-6
• 分子量: 448.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₅Cl₂N₉O₂
• 熔点: N/A
• 闪点: N/A

MLT-985用途

MLT-985是一种高选择性变构MALT1抑制剂,IC50值为3nm。

MLT-985名称

• 英文名: MLT-985

MLT-985生物活性

• 描述: MLT-985是一种高选择性变构MALT1抑制剂,IC50值为3nm。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> NF-κB信号通路 >> MALT1
• 参考文献:

  [1]. Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608.

MLT-985物理化学性质

• 分子式: C₁₇H₁₅Cl₂N₉O₂
• 分子量: 448.27

MLT-985靶点实验

查看更多实验

实验名称：Anti-autoimmune disease activity in OFA rat model of T-cell dependent B cell response... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4705973

实验名称：Anti-autoimmune disease activity in OFA rat model of T-cell dependent B cell response... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4705972

实验名称：Oral bioavailability in Sprague-Dawley rat at 3 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705951

实验名称：Growth inhibition of human BJAB cells grown in soft agar at 19.5 to 10000 nM 来源：ChEMBL 靶标：BJAB External Id：CHEMBL4705953

实验名称：Growth inhibition of human OCILY3 cells grown in soft agar at 19.5 to 10000 nM 来源：ChEMBL 靶标：OCI-Ly3 External Id：CHEMBL4705952

实验名称：Inhibition of MALT1 in human OCILY3 cells assessed as reduction in CYLD cleavage incu... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4705955

实验名称：Inhibition of MALT1 in human OCILY3 cells assessed as reduction in BCL10 cleavage inc... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4705954

实验名称：Inhibition of MALT1 in human OCILY3 cells assessed as reduction in IRAF4 cleavage inc... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4705957

实验名称：Inhibition of MALT1 in human OCILY3 cells assessed as reduction in RELB cleavage incu... 来源：ChEMBL 靶标：Mucosa-associated lymphoid tissue lymphoma translocation protein 1 External Id：CHEMBL4705956

实验名称：Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL4705943

共70条，当前第1页，共7页

1

2

3

4

5