LasR-IN-4

• 常用名: LasR-IN-4
• 英文名: LasR-IN-4
• CAS号: 183488-96-2
• 分子量: 292.38
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₀N₄
• 熔点: N/A
• 闪点: N/A

LasR-IN-4用途

LasR-IN-4是一种有效的LasR抑制剂。LasR-IN-4可以抑制铜绿假单胞菌及其生物膜的形成、绿脓杆菌素的产生和鼠李糖脂的产生[1]。

LasR-IN-4名称

• 英文名: LasR-IN-4

LasR-IN-4生物活性

• 描述: LasR-IN-4是一种有效的LasR抑制剂。LasR-IN-4可以抑制铜绿假单胞菌及其生物膜的形成、绿脓杆菌素的产生和鼠李糖脂的产生[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  MIC: 56.25 μg/mL (P. aeruginosa)[1]

• 体外研究: LasR-IN-4(化合物3d)对铜绿假单胞菌具有抑制活性,MIC为56.25μg/mL,分别抑制71.70%、68.70%和54.00%的生物膜形成、绿脓杆菌素生成和鼠李糖脂生成[1]。
• 参考文献:

  [1]. Abd El-Aleam RH, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629.

LasR-IN-4物理化学性质

• 分子式: C₁₈H₂₀N₄
• 分子量: 292.38
• InChIKey: MTCZGPPSHVGCKQ-UHFFFAOYSA-N
• SMILES: CN1CCN(c2ccc(-c3nc4ccccc4[nH]3)cc2)CC1

LasR-IN-4靶点实验

查看更多实验

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of ... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5110428

实验名称：Antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as inhibiti... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL5110429

实验名称：Cholinesterase Activity Assay from Article 10.1016/j.bioorg.2017.04.018: "Novel multi... 来源：BindingDB 靶标：N/A External Id：BindingDB_7949_1

实验名称：Cytotoxicity against human HDFa cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110438

实验名称：Selectivity index, ratio of IC50 for human HDFa cells to MIC for antibacterial activi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110439

实验名称：Inhibition of quorum sensing system in Pseudomonas aeruginosa assessed as downregulat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110440

实验名称：Inhibition of quorum sensing system in Pseudomonas aeruginosa assessed as downregulat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110441

实验名称：Antibacterial activity against Pseudomonas aeruginosa assessed as inhibition of bacte... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL5110434

实验名称：Inhibition of quorum sensing system in Pseudomonas aeruginosa assessed as inhibition ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110435

实验名称：Inhibition of quorum sensing system in Pseudomonas aeruginosa assessed as inhibition ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5110436

共14条，当前第1页，共2页

1

2