IPN-60090

• 常用名: IPN-60090
• 英文名: IPN60090
• CAS号: 1853164-83-6
• 分子量: 532.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₇F₃N₈O₃
• 熔点: N/A
• 闪点: N/A

IPN-60090用途

IPN-60090 是一种口服有效、选择性的肾脏型谷氨酰胺酶 GLS1 抑制剂。GLS1 是代谢能生产中一种重要的酶。IPN-60090 可以用于 GLS1 介导的疾病的研究。

IPN-60090名称

• 英文名: IPN-60090

IPN-60090生物活性

• 描述: IPN-60090 是一种口服有效、选择性的肾脏型谷氨酰胺酶 GLS1 抑制剂。GLS1 是代谢能生产中一种重要的酶。IPN-60090 可以用于 GLS1 介导的疾病的研究。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 靶点实验:

  GLS1[1]

• 体外研究: IPN-60090(示例1)具有对抗GLS1的IC50和对抗<100 nM的A549细胞增殖的EC50[2]。
• 参考文献:

  [1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2.

  [2]. Philip Jones, et al. Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide. US20170174661A1.

IPN-60090物理化学性质

• 分子式: C₂₄H₂₇F₃N₈O₃
• 分子量: 532.52
• InChIKey: GEHZIZWHNLQFAS-OAHLLOKOSA-N
• SMILES: CNC(=O)c1cn(CC(F)CCc2ccc(NC(=O)Cc3cc(OC4CC(F)(F)C4)cc(C)n3)nn2)nn1

IPN-60090靶点实验

查看更多实验

实验名称：Protein binding in rat plasma at 5 uM measured after 5 hrs by LC-MS based equilibrium... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676628

实验名称：Antitumor activity against human Ru337 cells xenografted in NSG mouse assessed as tum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676660

实验名称：Protein binding in dog plasma at 5 uM measured after 5 hrs by LC-MS based equilibrium... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676627

实验名称：In vivo inhibition of GLS1 in NSG mouse xenografted with human Ru337 cells assessed a... 来源：ChEMBL 靶标：Glutaminase kidney isoform, mitochondrial External Id：CHEMBL4676659

实验名称：Intrinsic clearance in dog hepatocytes assessed per kg protein at 2 uM measured after... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676630

实验名称：Intrinsic clearance in human hepatocytes assessed per kg protein at 2 uM measured aft... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676629

实验名称：Antitumor activity against human Ru337 cells xenografted in NSG mouse assessed as tum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676661

实验名称：Permeability across basolateral to apical side in human Caco-2 cells at 10 uM measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676632

实验名称：Intrinsic clearance in rat hepatocytes assessed per kg protein at 2 uM measured after... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676631

实验名称：Thermodynamic aqueous solubility of compound in pH 7 phosphate buffer incubated for 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676601

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