Sirt2的-IN-1

• 常用名: Sirt2的-IN-1
• 英文名: Sirt2-IN-1
• CAS号: 1862238-00-3
• 分子量: 557.69
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₇N₇O₂S₂
• 熔点: N/A
• 闪点: N/A

Sirt2的-IN-1用途

Sirt2-IN-1 (Compound 9) 是一种 sirtuin 2 (Sirt2) 抑制剂,IC50 为 163 nM。

Sirt2的-IN-1名称

• 中文名: Sirt2的-IN-1
• 英文名: Sirt2-IN-1

Sirt2的-IN-1生物活性

• 描述: Sirt2-IN-1 (Compound 9) 是一种 sirtuin 2 (Sirt2) 抑制剂,IC50 为 163 nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
  研究领域 >> 炎症/免疫
• 靶点实验:

  SIRT2:163 nM (IC50)

• 参考文献:

  [1]. Schiedel M, et al. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.

Sirt2的-IN-1物理化学性质

• 分子式: C₂₈H₂₇N₇O₂S₂
• 分子量: 557.69
• InChIKey: YWLNYZXFIAFWSF-UHFFFAOYSA-N
• SMILES: Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(Cc5ccccc5)nn4)c3)s2)n1
• 储存条件: 2-8℃

Sirt2的-IN-1靶点实验

查看更多实验

实验名称：Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-ter... 来源：ChEMBL 靶标：Nuclear receptor corepressor 2 External Id：CHEMBL5374956

实验名称：Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC2 (1 to 488 re... 来源：ChEMBL 靶标：Histone deacetylase 2 External Id：CHEMBL5374955

实验名称：Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 4... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL5374953

实验名称：Cytotoxicity against human PC-3M-luc cells assessed as inhibition of cell growth at 5... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374982

实验名称：Inhibition of recombinant human Sirt3 (118 to 395 residues) expressed in Escherichia ... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL5374951

实验名称：Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth at 1 mM i... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5374980

实验名称：Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth at 3.2 mM... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5374981

实验名称：Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 re... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL5374949

实验名称：Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia c... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL5374946

实验名称：Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth at 0.1 mM... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5374979

共16条，当前第1页，共2页

1

2