伊匹妥英

• 常用名: 伊匹妥英
• 英文名: Imepitoin
• CAS号: 188116-07-6
• 分子量: 279.722
• 密度: 1.4±0.1 g/cm3
• 沸点: 421.8±55.0 °C at 760 mmHg
• 分子式: C₁₃H₁₄ClN₃O₂
• 熔点: N/A
• 闪点: 208.9±31.5 °C

伊匹妥英用途

AWD 131-138(Imepitoin)是低亲和力的部分苯二氮(benzodiazepine)受体激动剂,有抗痉挛和抗焦虑作用。

伊匹妥英名称

• 中文名: 伊匹妥英
• 英文名: 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one

伊匹妥英生物活性

• 描述: AWD 131-138(Imepitoin)是低亲和力的部分苯二氮(benzodiazepine)受体激动剂,有抗痉挛和抗焦虑作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Sigel E, et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site. Neurosci Lett. 1998 Apr 3;245(2):85-8.

  [2]. Yasar S, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65.

  [3]. Loscher W, et al. Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. Epilepsia. 2004 Oct;45(10):1228-39.

伊匹妥英物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 421.8±55.0 °C at 760 mmHg
• 分子式: C₁₃H₁₄ClN₃O₂
• 分子量: 279.722
• 闪点: 208.9±31.5 °C
• 精确质量: 279.077454
• PSA: 45.14000
• LogP: 0.04
• InChIKey: IQHYCZKIFIHTAI-UHFFFAOYSA-N
• SMILES: O=C1N=C(N2CCOCC2)CN1c1ccc(Cl)cc1
• 外观性状: white solid
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.664
• 储存条件: -20℃

伊匹妥英靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Binding affinity to Wistar rat benzodiazepine receptor 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL862013

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Partition coefficient of the compound, log P 来源：ChEMBL 靶标：N/A External Id：CHEMBL862012

实验名称：Neurotoxicological activity in rat after oral administration by rotarod test 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL862019

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伊匹妥英英文别名

• 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one
• 1-(4-Chlorophenyl)-4-(4-morpholinyl)-1,5-dihydro-2H-imidazol-2-one
• UNII-19V39682LI
• 1-(4-Chlorophenyl)-4-(morpholin-4-yl)-1,5-dihydro-2H-imidazol-2-one
• AWD 131-138
• Imepitoin