HX 531

• 常用名: HX 531
• 英文名: HX 531
• CAS号: 188844-34-0
• 分子量: 483.55800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₉N₃O₄
• 熔点: N/A
• 闪点: N/A

HX 531用途

HX531是一种有效的RXR拮抗剂,IC50为18 nM[1]。研究表明,它可以降低高脂饮食小鼠的白色脂肪组织、骨骼肌和肝脏中的甘油三酯含量[2]。

HX 531名称

• 英文名: 4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b ]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

HX 531生物活性

• 描述: HX531是一种有效的RXR拮抗剂,IC50为18 nM[1]。研究表明,它可以降低高脂饮食小鼠的白色脂肪组织、骨骼肌和肝脏中的甘油三酯含量[2]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
• 靶点实验:

  RXR:18 nM (IC50)

• 参考文献:

  [1]. Konta T, et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001 Apr 20;276(16):12697-701.

  [2]. Yamauchi T, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest. 2001 Oct;108(7):1001-13.

HX 531物理化学性质

• 分子式: C₂₉H₂₉N₃O₄
• 分子量: 483.55800
• 精确质量: 483.21600
• PSA: 98.72000
• LogP: 6.91620
• InChIKey: SXKPGYKPQPYJER-UHFFFAOYSA-N
• SMILES: CN1c2ccc([N+](=O)[O-])cc2N=C(c2ccc(C(=O)O)cc2)c2cc3c(cc21)C(C)(C)CCC3(C)C
• 储存条件: -20°C，密闭，干燥

HX 531靶点实验

查看更多实验

实验名称：Inhibition of transcriptional activation in COS cells expressing murine retinoid X re... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-beta External Id：CHEMBL801583

实验名称：Human Retinoid X receptor-alpha (2B. Retinoid X receptors) 来源：IUPHAR-DB 靶标：Retinoid X receptor-alpha (2B. Retinoid X receptors) [Homo sapiens] External Id：610_Human

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Inhibition of transcriptional activation in COS cells expressing murine retinoid X re... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-gamma External Id：CHEMBL799937

实验名称：Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL897937

实验名称：Antagonist activity at human RXRalpha expressed in EK293 cells assessed as inhibition... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL897938

实验名称：Antagonist activity at RXRbeta expressed in african green monkey COS1 cells assessed ... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-beta External Id：CHEMBL1024632

实验名称：Antagonist activity at RXRalpha expressed in african green monkey COS1 cells assessed... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL1024631

实验名称：Inhibition of transcriptional activation in COS cells expressing murine retinoid X re... 来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha External Id：CHEMBL801581

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

共11条，当前第1页，共2页

1

2