RL648_81

• 常用名: RL648_81
• 英文名: RL648_81
• CAS号: 1919050-87-5
• 分子量: 371.33
• 密度: 1.4±0.1 g/cm3
• 沸点: 412.8±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇F₄N₃O₂
• 熔点: N/A
• 闪点: 203.4±28.7 °C

RL648_81用途

RL648\U 81是一种特殊的KQT样亚家族2/3(KCNQ2/3)激活剂,EC50为190 nM。RL648\U 81有力地将KCNQ2/3通道的V1/2移向超极化电位。RL648\U 81不会移动KCNQ4或KCNQ5的V1/2。RL648\U 81有可能导致与神经元高兴奋性研究相关的神经系统疾病【1】。

RL648_81名称

• 英文名: RL648_81

RL648_81生物活性

• 描述: RL648\U 81是一种特殊的KQT样亚家族2/3(KCNQ2/3)激活剂,EC50为190 nM。RL648\U 81有力地将KCNQ2/3通道的V1/2移向超极化电位。RL648\U 81不会移动KCNQ4或KCNQ5的V1/2。RL648\U 81有可能导致与神经元高兴奋性研究相关的神经系统疾病【1】。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.

RL648_81物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 412.8±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇F₄N₃O₂
• 分子量: 371.33
• 闪点: 203.4±28.7 °C
• 精确质量: 371.125702
• LogP: 1.97
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.595

RL648_81靶点实验

查看更多实验

实验名称：Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV ... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL5130130

实验名称：Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL5130132

实验名称：Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL5130128

实验名称：Agonist activity at human Kv7.2/Kv7.3 expressed in HEK293 cells assessed as drug conc... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL4434268

实验名称：Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV m... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL5130129

实验名称：Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent ... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 2 External Id：CHEMBL5116578

实验名称：Agonist activity at human Kv7.3/Kv7.5 expressed in HEK293 cells assessed as drug conc... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 5 External Id：CHEMBL4434269

实验名称：Agonist activity at Kv7.2 W236L mutant (unknown origin) assessed as shifting of volta... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5116579

实验名称：Agonist activity at human Kv7.4 expressed in HEK293 cells assessed as drug concentrat... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 4 External Id：CHEMBL4434270

实验名称：Agonist activity at human Kv7.4/Kv7.5 expressed in HEK293 cells assessed as drug conc... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 4 External Id：CHEMBL4434271

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RL648_81英文别名

• Carbamic acid, N-[2-amino-3-fluoro-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]-, ethyl ester
• Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate
• Ethyl (2-amino-3-fluoro-4-{[4-(trifluoromethyl)benzyl]amino}phenyl)carbamate
• RL648_81