RL648_81

Modify Date: 2023-02-14 08:28:01

RL648_81 Structure
RL648_81 structure
Common Name RL648_81
CAS Number 1919050-87-5 Molecular Weight 371.33
Density 1.4±0.1 g/cm3 Boiling Point 412.8±45.0 °C at 760 mmHg
Molecular Formula C17H17F4N3O2 Melting Point N/A
MSDS N/A Flash Point 203.4±28.7 °C

 Use of RL648_81


RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research[1].

 Names

Name RL648_81
Synonym More Synonyms

 RL648_81 Biological Activity

Description RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research[1].
Related Catalog
References

[1]. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 412.8±45.0 °C at 760 mmHg
Molecular Formula C17H17F4N3O2
Molecular Weight 371.33
Flash Point 203.4±28.7 °C
Exact Mass 371.125702
LogP 1.97
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.595

 Synonyms

Carbamic acid, N-[2-amino-3-fluoro-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]-, ethyl ester
Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate
Ethyl (2-amino-3-fluoro-4-{[4-(trifluoromethyl)benzyl]amino}phenyl)carbamate
RL648_81
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  • Purity: 98.0%
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