哌唑嗪

• 常用名: 哌唑嗪
• 英文名: Prazosin
• CAS号: 19216-56-9
• 分子量: 383.40100
• 密度: 1.352g/cm3
• 沸点: 638.4ºC at 760mmHg
• 分子式: C₁₉H₂₁N₅O₄
• 熔点: 278-280ºC
• 闪点: 339.9ºC

哌唑嗪用途

Prazosin是α肾上腺素阻断剂，可作用于高血压、焦虑和恐慌症等。

哌唑嗪名称

• 中文名: 哌唑嗪
• 英文名: prazosin
• 中文别名: 1-(4-氨基-6,7-二甲氧基-2-喹唑啉基-4-(2-呋喃基羰基))哌嗪

哌唑嗪生物活性

• 描述: Prazosin是α肾上腺素阻断剂,可作用于高血压、焦虑和恐慌症等。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  天然产物 >> 生物碱
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Day HE, et al. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 Jul;13(2):115-39.

  [2]. Yu CX, et al. Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. Neurosci Lett. 2000 Mar 24;282(3):161-4.

哌唑嗪物理化学性质

• 密度: 1.352g/cm3
• 沸点: 638.4ºC at 760mmHg
• 熔点: 278-280ºC
• 分子式: C₁₉H₂₁N₅O₄
• 分子量: 383.40100
• 闪点: 339.9ºC
• 精确质量: 383.15900
• PSA: 107.68000
• LogP: 1.71760
• InChIKey: IENZQIKPVFGBNW-UHFFFAOYSA-N
• SMILES: COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC
• 蒸汽压: 3.4E-16mmHg at 25°C
• 折射率: 1.651
• 储存条件: 库房通风低温干燥

哌唑嗪毒性和生态

哌唑嗪安全信息

• 海关编码: 2934999090

哌唑嗪海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

哌唑嗪靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical m... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL643628

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Evaluated for blood pressure lowering activity in spontaneously hypertensive rats (ma... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL796880

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

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哌唑嗪英文别名

• [14C]-Prazosin
• Prazosinum [INN-Latin]
• Minipress
• (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone
• [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
• [125I]-Prazosin
• Prazosinum
• 4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl furan-2-yl ketone
• [Bodipyl-FL]-Prazosin
• Prazosine
• Prazosina
• Furazosin
• Prazosina [INN-Spanish]
• 2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline
• Prazosine [INN-French]
• Lentopres