MRTF/SRF-IN-1

• 常用名: MRTF/SRF-IN-1
• 英文名: MRTF/SRF-IN-1
• CAS号: 1922098-90-5
• 分子量: 473.87
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₉ClF₃N₃O₂
• 熔点: N/A
• 闪点: N/A

MRTF/SRF-IN-1用途

MRTF/SRF-IN-1(实施例41)是肌卡蛋白相关转录因子和血清反应因子(MRTF/SRF)的抑制剂。MRTF/SRF-IN-1可用于预防癌症和纤维化的研究[1]。

MRTF/SRF-IN-1名称

• 英文名: MRTF/SRF-IN-1

MRTF/SRF-IN-1生物活性

• 描述: MRTF/SRF-IN-1(实施例41)是肌卡蛋白相关转录因子和血清反应因子(MRTF/SRF)的抑制剂。MRTF/SRF-IN-1可用于预防癌症和纤维化的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 参考文献:

  [1]. Larsen Scott D, et al. Preparation of substituted piperidine-3-carboxamides as inhibitors of myocardin-related transcription factor and serum response factor (MTRF/SRF)-mediated gene transcription. World Intellectual Property Organization, WO2016073847 A2. 2016-05-12.

MRTF/SRF-IN-1物理化学性质

• 分子式: C₂₄H₁₉ClF₃N₃O₂
• 分子量: 473.87

MRTF/SRF-IN-1靶点实验

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实验名称：AUC (0 to 7 hrs) in CD-1 mouse at 20 mg/kg, po administered via gavage as single dose... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4010979

实验名称：Inhibition of Rho/MRTF/SRF pathway in human primary dermal fibroblasts assessed as in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4010977

实验名称：AUC (0 to 7 hrs) in CD-1 mouse at 10 mg/kg, ip administered as single dose by LC-MS/M... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4010978

实验名称：Thermodynamic aqueous solubility of the compound in water by nitrogen detection metho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4010975

实验名称：Half life in CD-1 mouse liver microsomes at 1 uM in presence of NADPH by LC-MS/MS ana... 来源：ChEMBL 靶标：Liver External Id：CHEMBL4010974

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