ACPT-II

• 常用名: ACPT-II
• 英文名: ACPT-II
• CAS号: 195209-04-2
• 分子量: 217.18
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₁₁NO₆
• 熔点: N/A
• 闪点: N/A

ACPT-II用途

ACPT-II是III组mGluRs的激动剂,具有多种生物活性,包括神经保护、抗惊厥和抗焦虑样作用[1][2][3][4][5]。

ACPT-II名称

• 英文名: acpt-ii

ACPT-II生物活性

• 描述: ACPT-II是III组mGluRs的激动剂,具有多种生物活性,包括神经保护、抗惊厥和抗焦虑样作用[1][2][3][4][5]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29.

  [2]. Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.

  [3]. Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26(1):99-113.

  [4]. Chapman AG, et al. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424(2):107-13.

  [5]. Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57(3):227-34.

ACPT-II物理化学性质

• 分子式: C₈H₁₁NO₆
• 分子量: 217.18
• 精确质量: 217.05900
• PSA: 137.92000
• 储存条件: -20°C，密闭，干燥

ACPT-II靶点实验

查看更多实验

实验名称：Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL717753

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 4 External Id：CHEMBL1110789

实验名称：Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL709772

实验名称：Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 8 External Id：CHEMBL1110799

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 6 External Id：CHEMBL1110795

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

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