ZEN-3219

• 常用名: ZEN-3219
• 英文名: ZEN-3219
• CAS号: 1952264-34-4
• 分子量: 322.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₈N₂O₃
• 熔点: N/A
• 闪点: N/A

ZEN-3219用途

ZEN-3219 是一种 BET 抑制剂,抑制 BRD4(BD1),BRD4(BD2) 和 BRD4(BD1BD2) 的 IC50 分别为 0.48, 0.16 和 0.47 μM。ZEN-3219 可用于形成 PROTAC 分子,从而诱导 BRD4 降解。

ZEN-3219名称

• 中文名: ZEN-3219
• 英文名: ZEN-3219

ZEN-3219生物活性

• 描述: ZEN-3219 是一种 BET 抑制剂,抑制 BRD4(BD1),BRD4(BD2) 和 BRD4(BD1BD2) 的 IC50 分别为 0.48, 0.16 和 0.47 μM。ZEN-3219 可用于形成 PROTAC 分子,从而诱导 BRD4 降解。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  BRD4 (BD1):0.48 μM (IC50)

  BRD4 (BD2):0.16 μM (IC50)

  BRD4(BD1BD2):0.47 μM (IC50)

• 参考文献:

  [1]. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211.

ZEN-3219物理化学性质

• 分子式: C₁₉H₁₈N₂O₃
• 分子量: 322.36
• InChIKey: IELJHNIVCXDKQD-UHFFFAOYSA-N
• SMILES: Cc1noc(C)c1-c1ccc(=O)n(Cc2ccc(C3CO3)cc2)c1
• 储存条件: -20°C，干燥，密封

ZEN-3219安全信息

• 危害码 (欧洲): Xi

ZEN-3219靶点实验

查看更多实验

实验名称：Irreversible inhibition of N-terminal His-tagged BRD4 (BD1)(unknown origin) assessed ... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236646

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236667

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236666

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236669

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236668

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236665

实验名称：Binding affinity to BRPF1 (unknown origin) assessed as change in melting temperature ... 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4236675

实验名称：Binding affinity to P300 (unknown origin) assessed as change in melting temperature a... 来源：ChEMBL 靶标：Histone acetyltransferase p300 External Id：CHEMBL4236674

实验名称：Binding affinity to N-terminal His-tagged BRD4 (BD1) (unknown origin) assessed as cha... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4236645

实验名称：Binding affinity to CREBBP (unknown origin) assessed as change in melting temperature... 来源：ChEMBL 靶标：CREB-binding protein External Id：CHEMBL4236676

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