KCL-286

• 常用名: KCL-286
• 英文名: KCL-286
• CAS号: 1952276-71-9
• 分子量: 334.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₄N₂O₄
• 熔点: N/A
• 闪点: N/A

KCL-286用途

KCL-286 是一种口服有效的视黄酸受体 (RAR/RXR) β2 激动剂,对脊髓损伤 (SCI) 有改善作用。

KCL-286名称

• 英文名: KCL-286

KCL-286生物活性

• 描述: KCL-286 是一种口服有效的视黄酸受体 (RAR/RXR) β2 激动剂,对脊髓损伤 (SCI) 有改善作用。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
• 靶点实验:

  RAR β2[1]

• 参考文献:

  [1]. Goncalves MB, et al. Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-β agonist for treatment of spinal cord injury, in male healthy participants. Br J Clin Pharmacol. 2023 Jul 15..

KCL-286物理化学性质

• 分子式: C₁₉H₁₄N₂O₄
• 分子量: 334.33

KCL-286靶点实验

查看更多实验

实验名称：Intrinsic clearance in human microsomes assessed per mg protein after 45 mins in pres... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401926

实验名称：Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv or 1 to 10 mg/kg, po by LC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401927

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv or 1 to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401928

实验名称：Half life in Sprague-Dawley rat at 0.5 mg/kg, iv or 1 to 10 mg/kg, po by LC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401929

实验名称：Selectivity ratio of EC50 for GAL4-fused mouse RARalpha LBD expressed in COS-7 cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401914

实验名称：Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hr... 来源：ChEMBL 靶标：Retinoic acid receptor gamma External Id：CHEMBL4401915

实验名称：Selectivity ratio of EC50 for GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401916

实验名称：Octanol/buffer partition coefficient, log D of the compound at pH 7.4 by shake flask ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401917

实验名称：Apparent permeability in MDCK-MDR1 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401919

实验名称：Efflux ratio of apparent permeability in MDCK-MDR1 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4401920

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