Farglitazar

• 常用名: Farglitazar
• 英文名: Farglitazar
• CAS号: 196808-45-4
• 分子量: 546.61200
• 密度: N/A
• 沸点: 793.7ºC at 760 mmHg
• 分子式: C₃₄H₃₀N₂O₅
• 熔点: N/A
• 闪点: 433.8ºC

Farglitazar用途

法格列他扎尔是一种PPARγ激动剂,对2型糖尿病患者具有显著的治疗益处,如血糖控制。

Farglitazar名称

• 英文名: (2S)-2-(2-benzoylanilino)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid

Farglitazar生物活性

• 描述: 法格列他扎尔是一种PPARγ激动剂,对2型糖尿病患者具有显著的治疗益处,如血糖控制。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Chen L, Yang B, McNulty JA, et al. GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats. J Pharmacol Exp Ther. 2005;312(2):718-725.

Farglitazar物理化学性质

• 沸点: 793.7ºC at 760 mmHg
• 分子式: C₃₄H₃₀N₂O₅
• 分子量: 546.61200
• 闪点: 433.8ºC
• 精确质量: 546.21500
• PSA: 101.66000
• LogP: 6.68330
• InChIKey: ZZCHHVUQYRMYLW-HKBQPEDESA-N
• SMILES: Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC(Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1
• 蒸汽压: 1.45E-26mmHg at 25°C
• 折射率: 1.639

Farglitazar靶点实验

查看更多实验

实验名称：Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by ... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL3052672

实验名称：Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by ... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL3052673

实验名称：Solubility in simulated gastric fluid. 来源：ChEMBL 靶标：N/A External Id：CHEMBL633645

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Anti-diabetic activity in ob/ob mouse assessed as change in serum insulin levels at 3... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4139889

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：Anti-diabetic activity in ob/ob mouse assessed as change in serum glucose levels at 3... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4139887

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

实验名称：p53 small molecule agonists, cell-based qHTS assay 来源：824 External Id：P53344

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Farglitazar英文别名

• N-(o-Benzoylphenyl)-O-(2-(5-methyl-2-phenyl-4-oxazolyl)ethyl)-L-tyrosine
• L-Tyrosine,N-(2-benzoylphenyl)-o-(2-(5-methyl-2-phenyl-4-oxazolyl)ethyl)
• Farglitazar
• N-(2-benzoylphenyl)-O-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yI)ethyl]-L-tyrosine
• (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}-propionic acid
• 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID