SN 003

• 常用名: SN 003
• 英文名: SN 003
• CAS号: 197801-88-0
• 分子量: 355.43400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₅N₅O₂
• 熔点: N/A
• 闪点: N/A

SN 003用途

SN003 是促肾上腺皮质激素释放因子受体 1 (CRFR 1) 的可逆拮抗剂 (IC50 = 241 nM),比 CRFR 2 拮抗效果高 1000 多倍。SN003 在体外抑制 CRF 诱导的促肾上腺皮质激素 (ACTH) 释放。 SN003 可减轻大鼠的抑郁样行为。

SN 003名称

• 英文名: 1-(1-Methoxy-2-butanyl)-N-(4-methoxy-2-methylphenyl)-6-methyl-1H- [1,2,3]triazolo[4,5-c]pyridin-4-amine

SN 003生物活性

• 描述: SN003 是促肾上腺皮质激素释放因子受体 1 (CRFR 1) 的可逆拮抗剂 (IC50 = 241 nM),比 CRFR 2 拮抗效果高 1000 多倍。SN003 在体外抑制 CRF 诱导的促肾上腺皮质激素 (ACTH) 释放。 SN003 可减轻大鼠的抑郁样行为。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34.

  [2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774.

  [3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007.

SN 003物理化学性质

• 分子式: C₁₉H₂₅N₅O₂
• 分子量: 355.43400
• 精确质量: 355.20100
• PSA: 74.09000
• LogP: 3.86580
• InChIKey: FZMBHAQCHCEGNN-UHFFFAOYSA-N
• SMILES: CCC(COC)n1nnc2c(Nc3ccc(OC)cc3C)nc(C)cc21

SN 003靶点实验

查看更多实验

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实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

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