铁冬青酸

• 常用名: 铁冬青酸
• 英文名: Rutundic acid
• CAS号: 20137-37-5
• 分子量: 488.699
• 密度: 1.2±0.1 g/cm3
• 沸点: 622.8±55.0 °C at 760 mmHg
• 分子式: C₃₀H₄₈O₅
• 熔点: 272-274℃
• 闪点: 344.5±28.0 °C

铁冬青酸用途

Rotundic acid 是一种从圆形肠球菌 (I. rotunda) 中获得的三萜类化合物,可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。Rotundic acid 具有抗炎和保护心脏的能力。

铁冬青酸名称

• 中文名: 救必应酸
• 英文名: (1R,2R,4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-1,10-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
• 中文别名: 铁冬青酸

铁冬青酸生物活性

• 描述: Rotundic acid 是一种从圆形肠球菌 (I. rotunda) 中获得的三萜类化合物,可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。Rotundic acid 具有抗炎和保护心脏的能力。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT
• 靶点实验:

  Akt

  mTOR

  p38 MAPK

• 参考文献:

  [1]. Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545.

铁冬青酸物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 622.8±55.0 °C at 760 mmHg
• 熔点: 272-274℃
• 分子式: C₃₀H₄₈O₅
• 分子量: 488.699
• 闪点: 344.5±28.0 °C
• 精确质量: 488.350189
• PSA: 97.99000
• LogP: 5.75
• InChIKey: YLHQFGOOMKJFLP-LTFXOGOQSA-N
• SMILES: CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CCC(O)C(C)(CO)C5CCC43C)C2C1(C)O
• 外观性状: 粉末
• 蒸汽压: 0.0±4.1 mmHg at 25°C
• 折射率: 1.581
• 储存条件: -20℃

铁冬青酸靶点实验

查看更多实验

实验名称：Cytotoxicity against human NCI-H446 cells after 24 hrs by MTT assay 来源：ChEMBL 靶标：NCI-H446 External Id：CHEMBL2379690

实验名称：Cytotoxicity against human MCF7 cells at 10 uM after 48 hrs 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1272853

实验名称：Cytotoxicity against human NCI-H460 cells at 10 uM after 48 hrs 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL1272854

实验名称：Cytotoxicity against human HT-29 cells at 10 uM after 48 hrs 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1272855

实验名称：Anticomplement activity in New Zealand White rabbit erythrocytes assessed as concentr... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL4004087

实验名称：Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate asse... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL2089751

实验名称：Cytotoxicity against human BV2 cells assessed as survival rate at 250 ug/ml 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL4629344

实验名称：Anticomplement activity in sheep erythrocytes assessed as concentration required for ... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL4004086

实验名称：Inhibition of LPS-induced IL-1beta production in human BV2 cells at 250 ug/ml preincu... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL4629349

实验名称：Inhibition of LPS-induced TNF-alpha production in human BV2 cells at 250 ug/ml preinc... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL4629348

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铁冬青酸英文别名

• (3β)-3,19,23-Trihydroxyurs-12-en-28-oic acid
• Rotundic acid