FRα-IN-1

• 常用名: FRα-IN-1
• 英文名: FRα-IN-1
• CAS号: 2028296-64-0
• 分子量: 456.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₄N₆O₆
• 熔点: N/A
• 闪点: N/A

FRα-IN-1用途

FRα-IN-1(化合物4)是一种肿瘤靶向剂。FRα-IN-1对叶酸受体(FRα和FRβ)表达细胞显示出选择性抗癌活性[1]。

FRα-IN-1名称

• 英文名: FRα-IN-1

FRα-IN-1生物活性

• 描述: FRα-IN-1(化合物4)是一种肿瘤靶向剂。FRα-IN-1对叶酸受体(FRα和FRβ)表达细胞显示出选择性抗癌活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 叶酸
• 靶点实验:

  Folate receptor[1]

• 参考文献:

  [1]. Golani LK, et al. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorg Med Chem. 2020 Jun 15;28(12):115544.

FRα-IN-1物理化学性质

• 分子式: C₂₁H₂₄N₆O₆
• 分子量: 456.45
• InChIKey: HKWBWLAVVVNVRI-HNNXBMFYSA-N
• SMILES: Nc1nc2[nH]c(CCCNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1

FRα-IN-1靶点实验

查看更多实验

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624213

实验名称：Inhibition of GARFTase in Chinese Hamster D4 cells expressing human FRbeta assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624206

实验名称：Inhibition of GARFTase in Chinese Hamster RT16 cells expressing human FRalpha assesse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624205

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624208

实验名称：Inhibition of GARFTase in Chinese Hamster MTXRII-OuaR2-4 R2 cells expressing human PC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624207

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624210

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624209

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624212

实验名称：Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as redu... 来源：ChEMBL 靶标：Trifunctional purine biosynthetic protein adenosine-3 External Id：CHEMBL4624211

实验名称：Inhibition of GARFTase in Chinese Hamster PC43-10 cells expressing human RFC assessed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4624204

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