LSD1-IN-5

• 常用名: LSD1-IN-5
• 英文名: LSD1-IN-5
• CAS号: 2035912-55-9
• 分子量: 349.18
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₃BrN₂O₃
• 熔点: N/A
• 闪点: N/A

LSD1-IN-5用途

LSD1-in-1 (Compound 4e) 是一种有效、可逆的赖氨酸特异性去甲基化酶 (LSD1) 抑制剂,IC50 值为 121 nM。LSD1-in-1 能增加组蛋白 H3 Lys4 的二甲基化,但对 LSD1 的表达无作用。

LSD1-IN-5名称

• 英文名: LSD1-IN-5

LSD1-IN-5生物活性

• 描述: LSD1-in-1 (Compound 4e) 是一种有效、可逆的赖氨酸特异性去甲基化酶 (LSD1) 抑制剂,IC50 值为 121 nM。LSD1-in-1 能增加组蛋白 H3 Lys4 的二甲基化,但对 LSD1 的表达无作用。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
• 靶点实验:

  IC50: 121 nM (LSD1)[1]

• 参考文献:

  [1]. Duan YC, et al. Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation. Eur J Med Chem. 2017 Jan 27;126:246-258.

LSD1-IN-5物理化学性质

• 分子式: C₁₅H₁₃BrN₂O₃
• 分子量: 349.18
• InChIKey: ORMIOBDMECQFGI-SNAWJCMRSA-N
• SMILES: NC(=NO)c1cccc(C=Cc2cc(O)c(O)cc2Br)c1

LSD1-IN-5靶点实验

查看更多实验

实验名称：Effect on LSD1 expression in human MGC803 cells up to 2.5 uM after 5 days by DAPI sta... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL4002895

实验名称：Reversible inhibition of recombinant full length LSD1 (unknown origin) expressed in E... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL4002892

实验名称：Potency index, ratio of resveratrol IC50 to compound IC50 for recombinant full length... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL4002891

实验名称：Inhibition of LSD1 in human MGC803 cells assessed as induction of CD86 mRNA level in ... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL4002894

实验名称：Inhibition of LSD1 in human MGC803 cells assessed as accumulation of H3K4me2 after 5 ... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL4002893

实验名称：Inhibition of recombinant full length LSD1 (unknown origin) expressed in Escherichia ... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL4002889

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