Glycolithocholic acid-d4

• 常用名: Glycolithocholic acid-d4
• 英文名: Glycolithocholic Acid-d4 MaxSpec® Standard
• CAS号: 2044276-16-4
• 分子量: 437.649
• 密度: 1.1±0.1 g/cm3
• 沸点: 619.7±30.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉D₄NO₄
• 熔点: N/A
• 闪点: 328.6±24.6 °C

Glycolithocholic acid-d4用途

糖石胆酸-d4是氘标记的糖石胆酸。甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸,可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。

Glycolithocholic acid-d4名称

• 英文名: Glycolithocholic Acid-d4 MaxSpec® Standard

Glycolithocholic acid-d4生物活性

• 描述: 糖石胆酸-d4是氘标记的糖石胆酸。甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸,可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 体外研究: 甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸,可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。
• 参考文献:

  [1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91.

  [2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629.

  [3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405.

  [4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

Glycolithocholic acid-d4物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 619.7±30.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉D₄NO₄
• 分子量: 437.649
• 闪点: 328.6±24.6 °C
• 精确质量: 437.344330
• LogP: 5.58
• 蒸汽压: 0.0±4.1 mmHg at 25°C
• 折射率: 1.533

Glycolithocholic acid-d4英文别名

• MFCD06658889
• Glycine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-
• N-[(3α,5β)-3-Hydroxy-24-oxo(2,2,4,4-2H4)cholan-24-yl]glycine
• Glycolithocholic Acid-d4