甘氨石胆酸

• 常用名: 甘氨石胆酸
• 英文名: Glycolithocholic acid
• CAS号: 474-74-8
• 分子量: 433.62400
• 密度: 1.112g/cm3
• 沸点: 619.7ºC at 760mmHg
• 分子式: C₂₆H₄₃NO₄
• 熔点: 212-214°C (lit.)
• 闪点: 328.6ºC

甘氨石胆酸用途

甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。糖石胆酸可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。

甘氨石胆酸名称

• 中文名: 甘氨石胆酸
• 英文名: glycolithocholic acid

甘氨石胆酸生物活性

• 描述: 甘胆酸是一种内源性代谢产物,是一种甘氨酸结合的次级胆汁酸。糖石胆酸可用于诊断溃疡性结肠炎(UC)、非酒精性脂肪性肝炎(NASH)和原发性硬化性胆管炎(PSC)[1][2][3][4]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 体内研究: 溃疡性结肠炎(UC)患者的糖石胆酸浓度显著低于健康对照组(HCs)[2]。
• 参考文献:

  [1]. Tanno N, et, al. Biliary lipid composition in heterozygous familial hypercholesterolemia and influence of treatment with probucol. Dig Dis Sci. 1994 Jul;39(7):1586-91.

  [2]. Ang ZH, et, al. Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis. World J Gastroenterol. 2021 Jun 28;27(24):3609-3629.

  [3]. Bansal S, et, al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites. J Pharmacol Exp Ther. 2019 Jun;369(3):389-405.

  [4]. Sanyal AJ, et, al. Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases. JHEP Rep. 2021 Feb 19;3(3):100255.

甘氨石胆酸物理化学性质

• 密度: 1.112g/cm3
• 沸点: 619.7ºC at 760mmHg
• 熔点: 212-214°C (lit.)
• 分子式: C₂₆H₄₃NO₄
• 分子量: 433.62400
• 闪点: 328.6ºC
• 精确质量: 433.31900
• PSA: 86.63000
• LogP: 5.01420
• InChIKey: XBSQTYHEGZTYJE-OETIFKLTSA-N
• SMILES: CC(CCC(=O)NCC(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C
• 储存条件: 2-8°C

甘氨石胆酸毒性和生态

甘氨石胆酸安全信息

• 危害码 (欧洲): T

甘氨石胆酸靶点实验

查看更多实验

实验名称：Inhibition of human alpha-2,6-ST6GAL1 assessed as reduction in sialylated-product for... 来源：ChEMBL 靶标：Beta-galactoside alpha-2,6-sialyltransferase 1 External Id：CHEMBL4775587

实验名称：Inhibition of rat alpha-2,3-N-ST3GALIII assessed as reduction in sialylated-product f... 来源：ChEMBL 靶标：CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase External Id：CHEMBL4775585

实验名称：Inhibition of ephrin-A1-Fc binding to EphA2-Fc receptor (unknown origin) after 1 hr b... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL2329875

实验名称：Di-UB K63-2 Hydrolysis Assay from Article 10.1016/j.chembiol.2017.03.002: "Lithocholi... 来源：BindingDB 靶标：N/A External Id：BindingDB_7922_2

实验名称：Ub-AMC-Hydrolysis Assay from Article 10.1016/j.chembiol.2017.03.002: "Lithocholic Aci... 来源：BindingDB 靶标：N/A External Id：BindingDB_7922_1

实验名称：Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product for... 来源：ChEMBL 靶标：Sialyltransferase ST3Gal-I External Id：CHEMBL4775588

实验名称：Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product for... 来源：ChEMBL 靶标：Sialyltransferase ST3Gal-I External Id：CHEMBL4775589

实验名称：Antagonist activity at EphA2 in human PC3 cells assessed as inhibition of ephrin-A1-F... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL2329863

实验名称：TP_TRANSPORTER: inhibition of Estradiol-17beta-D-glucuronide uptake by Glycolithochol... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 11 External Id：CHEMBL2077124

实验名称：TP_TRANSPORTER: inhibition of Taurocholate uptake in the presence of Lithoglycocholat... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 4 External Id：CHEMBL2078614

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甘氨石胆酸英文别名

• Glycolithocholic acid
• 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid
• Lithocholic acid glycine conjugate
• Lithocholylglycine
• Glycolithocholate