HDAC3 Inhibitor

• 常用名: HDAC3 Inhibitor
• 英文名: HDAC3 Inhibitor (Histone Deacetylase 3)
• CAS号: 2044701-99-5
• 分子量: 337.42
• 密度: 1.140±0.06 g/cm3(Predicted)
• 沸点: 562.5±50.0 °C(Predicted)
• 分子式: C₂₀H₂₃N₃O₂
• 熔点: N/A
• 闪点: N/A

HDAC3 Inhibitor用途

HDAC3-IN-1(化合物5)是一种有效的选择性HDAC3抑制剂,IC50为5.96 nM【1】。

HDAC3 Inhibitor名称

• 中文名: 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-benzoicacid2-propylhydrazide
• 英文名: HDAC3 Inhibitor

HDAC3 Inhibitor生物活性

• 描述: HDAC3-IN-1(化合物5)是一种有效的选择性HDAC3抑制剂,IC50为5.96 nM【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  HDAC3:5.96 ± 0.0 nM (IC50)

  HDAC1:36.4 ± 0.2 nM (IC50)

  HDAC2:89.9 ± 0.7 nM (IC50)

• 参考文献:

  [1]. Moreno-Yruela C, Olsen CA. Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity. ACS Med Chem Lett. 2022 Mar 16;13(5):779-785.

HDAC3 Inhibitor物理化学性质

• 密度: 1.140±0.06 g/cm3(Predicted)
• 沸点: 562.5±50.0 °C(Predicted)
• 分子式: C₂₀H₂₃N₃O₂
• 分子量: 337.42
• InChIKey: MHZUZIALEUTHIU-JLHYYAGUSA-N
• SMILES: CCCNNC(=O)c1ccc(CNC(=O)C=Cc2ccccc2)cc1
• 储存条件: -20°C，密闭，干燥

HDAC3 Inhibitor靶点实验

查看更多实验

实验名称：Antiproliferative activity against human MV4-11 AML cells assessed as cell viability ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5043887

实验名称：Antiproliferative activity against human MV4-11 cells harboring wild type p53 assesse... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5506674

实验名称：Selectivity index, ratio of IC50 for inhibition of full length C-terminal His-tagged ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5128962

实验名称：Selectivity index, ratio of IC50 for inhibition of full length C-terminal His-tagged ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5128963

实验名称：Selectivity index, ratio of IC50 for inhibition of full length C-terminal His-tagged ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5128964

实验名称：Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as di... 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL5128965

实验名称：Selectivity index, ratio of IC50 for inhibition of full length C-terminal His-tagged ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5128961

实验名称：Up regulation of acetylated histoneH4 ine expression in human MV4-11 cells at 200 nM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043932

实验名称：Up regulation of acetylated histoneH4 in expression in human MV4-11 cells at 100 nM m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043931

实验名称：Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST... 来源：ChEMBL 靶标：Nuclear receptor corepressor 2 External Id：CHEMBL5128940

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