(S)-Erypoegin K

• 常用名: (S)-Erypoegin K
• 英文名: (S)-Erypoegin K
• CAS号: 2055053-90-0
• 分子量: 354.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈O₆
• 熔点: N/A
• 闪点: N/A

(S)-Erypoegin K用途

(S) -丹皮酚K是一种有效的抗癌剂。(S) -丹皮酚K对HL-60细胞具有较强的抗增殖活性。(S) -丹皮酚K诱导细胞凋亡[1]。

(S)-Erypoegin K名称

• 英文名: (S)-Erypoegin K

(S)-Erypoegin K生物活性

• 描述: (S) -丹皮酚K是一种有效的抗癌剂。(S) -丹皮酚K对HL-60细胞具有较强的抗增殖活性。(S) -丹皮酚K诱导细胞凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 体外研究: (S) -丹皮酚素K(0-1µM；48 h)对HL-60细胞显示出强大的抗增殖活性,IC50为90 nM【1】。(S) -赤霉素K(0.1,0.5µM；24小时)诱导caspase-3和−9以时间和剂量依赖性的方式在HL-60细胞中表达[1]。
• 参考文献:

  [1]. Hikita K, et al. Induction of enantio-selective apoptosis in human leukemia HL-60 cells by (S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana. Bioorg Med Chem. 2020 Jun 1;28(11):115490.

(S)-Erypoegin K物理化学性质

• 分子式: C₂₀H₁₈O₆
• 分子量: 354.35

(S)-Erypoegin K靶点实验

查看更多实验

实验名称：Cell cycle arrest in human MKN-1 cells assessed as accumulation at G2/M phase at 0.3 ... 来源：ChEMBL 靶标：MKN-1 External Id：CHEMBL4688779

实验名称：Cell cycle arrest in human MKN-1 cells assessed as accumulation at S phase at 0.3 uM ... 来源：ChEMBL 靶标：MKN-1 External Id：CHEMBL4688778

实验名称：Toxicity in KSN/Slc nude mouse xenografted with human GCIY cells assessed as effect o... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4688781

实验名称：Induction of apoptosis in human HL60 cells assessed as DNA ladder formation at 1 to 3... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4623144

实验名称：Antitumor activity against human GCIY cells xenografted in KSN/Slc nude mouse assesse... 来源：ChEMBL 靶标：GCIY External Id：CHEMBL4688780

实验名称：Induction of apoptosis in human HL60 cells assessed as nuclear condensation/fragmenta... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4623143

实验名称：Induction of apoptosis in human HL60 cells assessed as caspase 9 activation incubated... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4623146

实验名称：Induction of apoptosis in human HL60 cells assessed as caspase 3 activation incubated... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4623145

实验名称：Induction of apoptosis in human HL60 cells assessed as increase in MG level accumulat... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4623147

实验名称：Cell cycle arrest in human GCIY cells assessed as accumulation at G0/G1 phase at 0.3 ... 来源：ChEMBL 靶标：GCIY External Id：CHEMBL4688771

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