色氨酸A

• 常用名: 色氨酸A
• 英文名: Luotonin A
• CAS号: 205989-12-4
• 分子量: 285.30
• 密度: 1.4±0.1 g/cm3
• 沸点: 530.9±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁N₃O
• 熔点: N/A
• 闪点: 274.9±32.9 °C

色氨酸A用途

Luotonin A 是一种抗病毒 (antiviral) 和抗植物致病真菌 (fungus) 剂。Luotonin A 对烟草花叶病毒 (TMV) 具有良好的抗病毒活性。Luotonin A 对拓扑异构酶 I (topoisomerase I) 和拓扑异构酶 II (topoisomerase II) 也有一定的抑制活性。Luotonin A 具有抗肿瘤活性。

色氨酸A名称

• 中文名: 色氨酸A
• 英文名: luotonin A

色氨酸A生物活性

• 描述: Luotonin A 是一种抗病毒 (antiviral) 和抗植物致病真菌 (fungus) 剂。Luotonin A 对烟草花叶病毒 (TMV) 具有良好的抗病毒活性。Luotonin A 对拓扑异构酶 I (topoisomerase I) 和拓扑异构酶 II (topoisomerase II) 也有一定的抑制活性。Luotonin A 具有抗肿瘤活性。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773.

  [2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9.

色氨酸A物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 530.9±60.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁N₃O
• 分子量: 285.30
• 闪点: 274.9±32.9 °C
• 精确质量: 285.090210
• PSA: 47.78000
• LogP: 2.25
• InChIKey: LUMDXNLBIYLTER-UHFFFAOYSA-N
• SMILES: O=c1c2ccccc2nc2n1Cc1cc3ccccc3nc1-2
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.792
• 储存条件: -20°C，密闭，干燥

色氨酸A靶点实验

查看更多实验

实验名称：Inhibition of full-length recombinant human Top1 expressed in baculovirus infected Sf... 来源：ChEMBL 靶标：DNA topoisomerase 1 External Id：CHEMBL5114534

实验名称：In vitro inhibitory concentration against human lung large cell carcinoma cell line, ... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL874933

实验名称：Percent inhibitory activity of 0.5 uM of compound against growth of Saccharomyces cer... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL809780

实验名称：Cytotoxic activity against mouse leukemia P-388 cells 来源：ChEMBL 靶标：P388 External Id：CHEMBL758425

实验名称：Percent inhibitory activity of 1 uM of compound against growth of Saccharomyces cerev... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL809784

实验名称：Percent inhibitory activity of 0.5 uM of compound against growth of Saccharomyces cer... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL809781

实验名称：Percent inhibitory activity of 10 uM of compound against growth of Saccharomyces cere... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL809788

实验名称：Cytotoxicity against mouse P388 cells assessed as reduction in cell viability after 7... 来源：ChEMBL 靶标：P388 External Id：CHEMBL5386595

实验名称：In vitro inhibitory concentration against human lung large cell carcinoma cell line, ... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL874956

实验名称：Percent inhibitory activity of 1 uM of compound against growth of Saccharomyces cerev... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL809785

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色氨酸A英文别名

• Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one
• 3,2'-monomethylene-2-(quinol-2-yl)-4(3H)-quinazolinone
• LUOTONIN A
• 11,13-dihydroquino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11-one
• Luotonine A
• luotonin
• Quinolino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one