JNJ-64619178

• 常用名: JNJ-64619178
• 英文名: JNJ-64619178
• CAS号: 2086772-26-9
• 分子量: 483.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃BrN₆O₂
• 熔点: N/A
• 闪点: N/A

JNJ-64619178用途

JNJ-64619178 是一种伪不可逆的,选择性 PRMT5 抑制剂。

JNJ-64619178名称

• 中文名: JNJ-64619178
• 英文名: JNJ-64619178

JNJ-64619178生物活性

• 描述: JNJ-64619178 是一种伪不可逆的,选择性 PRMT5 抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
• 靶点实验:

  PRMT5[1]

• 参考文献:

  [1]. Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.

JNJ-64619178物理化学性质

• 分子式: C₂₂H₂₃BrN₆O₂
• 分子量: 483.36
• InChIKey: DBSMLQTUDJVICQ-CJODITQLSA-N
• SMILES: Nc1nc2cc(CCC3CC(n4ccc5c(N)ncnc54)C(O)C3O)ccc2cc1Br
• 外观性状: 粉末
• 储存条件: -20℃

JNJ-64619178靶点实验

查看更多实验

实验名称：Clearance in C57BL/6 mouse at 10 mg/kg, po or 2.5 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL5350342

实验名称：Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal H... 来源：ChEMBL 靶标：Protein arginine N-methyltransferase 5 External Id：CHEMBL4392561

实验名称：Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production afte... 来源：ChEMBL 靶标：Protein arginine N-methyltransferase 5 External Id：CHEMBL4392562

实验名称：Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM ... 来源：ChEMBL 靶标：Protein arginine N-methyltransferase 5 External Id：CHEMBL5544428

实验名称：Antiproliferation activity against human MOLM-13 cells assessed as cell viability inc... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL5544429

实验名称：Stability in mouse plasma assessed as compound remaining relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL4827798

实验名称：Antiproliferation activity against human Z138 cells assessed as cell viability incuba... 来源：ChEMBL 靶标：Z-138 External Id：CHEMBL5544430

实验名称：Antitumor activity against human NCI-H1048 cells xenografted in mouse assessed as tum... 来源：ChEMBL 靶标：NCI-H1048 External Id：CHEMBL5350353

实验名称：Inhibition of PRMT5 in human NCI-H1048 cells assessed as reduction in dimethylation o... 来源：ChEMBL 靶标：Protein arginine N-methyltransferase 5 External Id：CHEMBL5350351

实验名称：Antitumor activity against human NCI-H1048 cells xenografted in mouse assessed as tum... 来源：ChEMBL 靶标：NCI-H1048 External Id：CHEMBL5350352

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