TMPRSS6-IN-1

• 常用名: TMPRSS6-IN-1
• 英文名: TMPRSS6-IN-1
• CAS号: 2088415-78-3
• 分子量: 676.85
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₄₀N₈O₄S₂
• 熔点: N/A
• 闪点: N/A

TMPRSS6-IN-1用途

TMPRSS6-IN-1(化合物8)是属于TTSP(跨膜丝氨酸蛋白酶)的TMPRSS6(基质蛋白酶-2)的有效抑制剂。TMPRSS6是一种II型TTSP,其基因减少将改善小鼠血色病和β地中海贫血的症状[1]。

TMPRSS6-IN-1名称

• 英文名: TMPRSS6-IN-1

TMPRSS6-IN-1生物活性

• 描述: TMPRSS6-IN-1(化合物8)是属于TTSP(跨膜丝氨酸蛋白酶)的TMPRSS6(基质蛋白酶-2)的有效抑制剂。TMPRSS6是一种II型TTSP,其基因减少将改善小鼠血色病和β地中海贫血的症状[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶
  研究领域 >> 其他
• 靶点实验:

  TMPRSS6 (Matriptase-2)[1]

• 参考文献:

  [1]. St-Georges C, et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem. 2017 Mar 31;129:110-123.

TMPRSS6-IN-1物理化学性质

• 分子式: C₃₃H₄₀N₈O₄S₂
• 分子量: 676.85

TMPRSS6-IN-1靶点实验

查看更多实验

实验名称：Selectivity index, ratio of Ki for competitive tight binding inhibition of recombinan... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553705

实验名称：Cytotoxicity against HEK cells assessed as reduction in cell viability measured for 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553713

实验名称：Selectivity index, ratio of IC50 for inhibition of human Matriptase transfected in HE... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553716

实验名称：Stability in Sprague-Dawley rat plasma assessed as parent compound remaining at 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553718

实验名称：Metabolic stability in Sprague-Dawley rat microsome assessed as half life measured fo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553719

实验名称：Metabolic stability in Sprague-Dawley rat microsome assessed as intrinsic clearance m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553720

实验名称：Apparent Permeability of compound in PBS buffer at pH 7.4 incubated for 17 hrs by PAM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5553721

实验名称：Inhibition of recombinant human C-terminal V5-His-tagged matriptase-2 expressed in Dr... 来源：ChEMBL 靶标：Transmembrane protease serine 6 External Id：CHEMBL4009363

实验名称：Disruption of epithelial integrity in human Caco-2 cells assessed as change in TEER m... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL5553723

实验名称：Stability in mouse plasma assessed as parent compound remaining after 24 hrs 来源：ChEMBL 靶标：Plasma External Id：CHEMBL4009362

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