Multi-kinase-IN-3

• 常用名: Multi-kinase-IN-3
• 英文名: Multi-kinase-IN-3
• CAS号: 2091950-43-3
• 分子量: 547.65
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₃₃N₅O₃
• 熔点: N/A
• 闪点: N/A

Multi-kinase-IN-3用途

多激酶-IN-3(化合物2)是一种有效的血管激酶抑制剂。多激酶-IN-3显示出对VEGFR-2和PDGFRβ的抑制活性,IC50值分别为58.3和55 nM[1]。

Multi-kinase-IN-3名称

• 英文名: Multi-kinase-IN-3

Multi-kinase-IN-3生物活性

• 描述: 多激酶-IN-3(化合物2)是一种有效的血管激酶抑制剂。多激酶-IN-3显示出对VEGFR-2和PDGFRβ的抑制活性,IC50值分别为58.3和55 nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> PDGFR
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  PDGFRβ:55 ± 2.6 nM (IC50)

  VEGFR-2:58.3 ± 5.9 nM (IC50)

• 参考文献:

  [1]. Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486.

Multi-kinase-IN-3物理化学性质

• 分子式: C₃₃H₃₃N₅O₃
• 分子量: 547.65

Multi-kinase-IN-3靶点实验

查看更多实验

实验名称：Inhibition of N-terminal GST-fused human PDGFRbeta cytoplasmic domain (557 to 1106 (e... 来源：ChEMBL 靶标：Platelet-derived growth factor receptor beta External Id：CHEMBL4623160

实验名称：Inhibition of N-terminal GST fused human VEGFR2 cytoplasmic domain (790 to 1356 (end)... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL4623159

实验名称：Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 resi... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL3993992

实验名称：Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 resi... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL3993991

实验名称：Inhibition of human N-terminal GST-tagged PDGFRbeta cytoplasmic domain (557 to 1106 r... 来源：ChEMBL 靶标：Platelet-derived growth factor receptor beta External Id：CHEMBL3993993

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