HTL22562

• 常用名: HTL22562
• 英文名: HTL22562
• CAS号: 2097085-63-5
• 分子量: 763.89
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₀H₄₉N₁₁O₅
• 熔点: N/A
• 闪点: N/A

HTL22562用途

HTL22562是一种降钙素基因相关肽(CGRP)受体拮抗剂,用于偏头痛的急性治疗。

HTL22562名称

• 英文名: HTL22562

HTL22562生物活性

• 描述: HTL22562是一种降钙素基因相关肽(CGRP)受体拮抗剂,用于偏头痛的急性治疗。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CGRP受体
  信号通路 >> 神经信号通路 >> CGRP受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bucknell SJ, et al. Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine. J Med Chem. 2020 Jul 23;63(14):7906-7920.

HTL22562物理化学性质

• 分子式: C₄₀H₄₉N₁₁O₅
• 分子量: 763.89

HTL22562靶点实验

查看更多实验

实验名称：Solubility of the compound at pH 8.2 using amorphous form of sample 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613007

实验名称：Protein binding in human plasma by high-throughput dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613006

实验名称：Solubility of the compound at pH 4 using amorphous form of sample 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613009

实验名称：Solubility of the compound at pH 5.7 using amorphous form of sample 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613008

实验名称：Antagonist activity at human adrenomedullin-1 receptor 来源：ChEMBL 靶标：Calcitonin receptor External Id：CHEMBL4612999

实验名称：Antagonist activity at human amylin-1 receptor 来源：ChEMBL 靶标：Calcitonin receptor External Id：CHEMBL4612998

实验名称：Agonist activity at MRGPX2 (unknown origin) at 10 uM relative to control 来源：ChEMBL 靶标：Mas-related G-protein coupled receptor member X2 External Id：CHEMBL4613001

实验名称：Antagonist activity at CHRM2 (unknown origin) at 10 uM relative to control 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2 External Id：CHEMBL4613000

实验名称：Protein binding in rat plasma by high-throughput dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613003

实验名称：Protein binding in cynomolgus monkey plasma by high-throughput dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL4613005

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