TRPM8 antagonist 3

更新时间：2026-07-08 06:39:02

TRPM8 antagonist 3结构式	常用名	TRPM8 antagonist 3	英文名	TRPM8 antagonist 3
	CAS号	2102179-29-1	分子量	292.31
	密度	N/A	沸点	N/A
	分子式	C₁₃H₁₂N₂O₄S	熔点	N/A
	MSDS	N/A	闪点	N/A

TRPM8 antagonist 3用途

TRPM8拮抗剂3是一种新型的TRPM8阻滞剂,其IC50值为11nM。

英文名	TRPM8 antagonist 3

描述	TRPM8拮抗剂3是一种新型的TRPM8阻滞剂,其IC50值为11nM。
相关类别	信号通路 >> 跨膜转运 >> TRP频道研究领域 >> 其他
参考文献	[1]. Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837.

分子式	C₁₃H₁₂N₂O₄S
分子量	292.31

实验名称：Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-...
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily M member 8
External Id：CHEMBL5265491

实验名称：Dissociation constant, pKa of the compound
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5265494

实验名称：Inhibition of ocular menthol challenge induced BALB/c mouse eye redness at 0.1% upto ...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL5265532

实验名称：Apparent permeability in HCECs at 0.1%
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5265531

实验名称：Inhibition of ocular menthol challenge induced BALB/c mouse behavioral response asses...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL5265534

实验名称：Inhibition of ocular menthol challenge induced BALB/c mouse eye inflammation at 0.1% ...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL5265533

实验名称：Inhibition of TRPV4 (unknown origin) upto 100 uM
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 4
External Id：CHEMBL5265528

实验名称：Lipophilicity, logD of the compound at pH 7.4
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5265495

实验名称：Inhibition of TRPV1 (unknown origin) upto 100 uM
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 1
External Id：CHEMBL5265527

实验名称：Metabolic stability in human liver S9 fraction assay as half life in presence of NADP...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5265511

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