DK419

• 常用名: DK419
• 英文名: DK419
• CAS号: 2102672-22-8
• 分子量: 407.70
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₈ClF₆N₃O
• 熔点: N/A
• 闪点: N/A

DK419用途

DK419 是一种有效、可口服的 Wnt/β-catenin 信号通路抑制剂,IC50 值为 0.19 μM。DK419 能降低 Axin2,β-catenin,c-Myc,Cyclin D1 和 Survivin 能够改变细胞内耗氧率,诱导 pAMPK 的产生。

DK419名称

• 中文名: DK419
• 英文名: DK419

DK419生物活性

• 描述: DK419 是一种有效、可口服的 Wnt/β-catenin 信号通路抑制剂,IC50 值为 0.19 μM。DK419 能降低 Axin2,β-catenin,c-Myc,Cyclin D1 和 Survivin 能够改变细胞内耗氧率,诱导 pAMPK 的产生。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号
• 靶点实验:

  Wnt/β-catenin[1]

• 参考文献:

  [1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442.

DK419物理化学性质

• 分子式: C₁₆H₈ClF₆N₃O
• 分子量: 407.70
• InChIKey: MWNNIGRGNSXNEA-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(Cl)cc2[nH]c(C(F)(F)F)nc12
• 储存条件: 2-8°C

DK419靶点实验

查看更多实验

实验名称：Antitumor activity against human CRC240 cells xenografted in NOD/SCID mouse at 1 mg/k... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4276082

实验名称：In vivo inhibition of Wnt/beta-catenin signaling pathway in NOD/SCID mouse xenografte... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276084

实验名称：Toxicity in NOD/SCID mouse xenografted with human CRC240 cells assessed as change in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276080

实验名称：Time at which plasma concentration stays above in vitro IC50 for antiproliferative ac... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276089

实验名称：In vivo inhibition of Wnt/beta-catenin signaling pathway in NOD/SCID mouse xenografte... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276086

实验名称：In vivo inhibition of Wnt/beta-catenin signaling pathway in NOD/SCID mouse xenografte... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276085

实验名称：Stimulation of mitochondrial respiration in human CCD-841-CoN cells assessed as incre... 来源：ChEMBL 靶标：CCD-841CoN External Id：CHEMBL4276088

实验名称：Induction of GFP-tagged Fzd1 (unknown origin) internalization expressed in human U2OS... 来源：ChEMBL 靶标：Frizzled-1 External Id：CHEMBL4276087

实验名称：AUC (0 to 72 hrs) in NOD/SCID mouse at 1 mg/kg, po by LC-MS/MS-based non-compartmenta... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276066

实验名称：Dose normalized AUC (0 to infinity) in NOD/SCID mouse at 1 mg/kg, po by LC-MS/MS-base... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4276065

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