BET-IN-2

• 常用名: BET-IN-2
• 英文名: BET-IN-2
• CAS号: 2104688-91-5
• 分子量: 363.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₉N₃O
• 熔点: N/A
• 闪点: N/A

BET-IN-2用途

BET-IN-2是 BET 的抑制剂,对BRD4-BD1的 IC50 为52 nM。

BET-IN-2名称

• 中文名: BET-IN-2
• 英文名: BET-IN-2

BET-IN-2生物活性

• 描述: BET-IN-2是 BET 的抑制剂,对BRD4-BD1的 IC50 为52 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  BRD4 BD1:52 nM (IC50)

• 参考文献:

  [1]. Hu J, et al. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. Eur J Med Chem. 2017 Sep 8;137:176-195.

BET-IN-2物理化学性质

• 分子式: C₂₃H₂₉N₃O
• 分子量: 363.50
• InChIKey: SVQCMDHUVKEZPE-DLBZAZTESA-N
• SMILES: Cc1ccc(C(C)Nc2ccc3c(c2)N(C2CC2)C(C)C(=O)N3C)c(C)c1
• 储存条件: 2-8°C，密封，干燥

BET-IN-2靶点实验

查看更多实验

实验名称：Inhibition of human partial length BRD3 bromodomain 2 (G306 to P416 residues) express... 来源：ChEMBL 靶标：Bromodomain-containing protein 3 External Id：CHEMBL4130856

实验名称：Inhibition of human partial length BRD4 bromodomain 1 long isoform (N44 to E168 resid... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL4130857

实验名称：Inhibition of human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residue... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL4130854

实验名称：Inhibition of human partial length BRD3 bromodomain 1 (P24 to E144 residues) expresse... 来源：ChEMBL 靶标：Bromodomain-containing protein 3 External Id：CHEMBL4130855

实验名称：Inhibition of human partial length BRD1 (E556 to A688 residues) expressed in Escheric... 来源：ChEMBL 靶标：Bromodomain-containing protein 1 External Id：CHEMBL4130852

实验名称：Inhibition of human partial length BRD2 bromodomain 1 long isoform (K71 to N194 resid... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL4130853

实验名称：Inhibition of human partial length BAZ2A (M1792 to L1905 residues) expressed in Esche... 来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2A External Id：CHEMBL4130850

实验名称：Inhibition of human partial length BAZ2B (S2054 to S2168 residues) expressed in Esche... 来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B External Id：CHEMBL4130851

实验名称：Inhibition of human partial length BRPF3 (E588 to G701 residues) expressed in Escheri... 来源：ChEMBL 靶标：Bromodomain and PHD finger-containing protein 3 External Id：CHEMBL4130864

实验名称：Inhibition of human partial length CECR2 (P423 to D543 residues) expressed in Escheri... 来源：ChEMBL 靶标：Cat eye syndrome critical region protein 2 External Id：CHEMBL4130865

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