GSK3036656

• 常用名: GSK3036656
• 英文名: GSK3036656
• CAS号: 2131798-12-2
• 分子量: 257.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₃BClNO₄
• 熔点: N/A
• 闪点: N/A

GSK3036656用途

GSK3036656(GSK070)是一种有效、选择性和口服活性的结核分枝杆菌亮氨酸tRNA合成酶抑制剂,IC50为0.20μM。GSK3036656可用于结核研究[1]。

GSK3036656名称

• 英文名: GSK3036656

GSK3036656生物活性

• 描述: GSK3036656(GSK070)是一种有效、选择性和口服活性的结核分枝杆菌亮氨酸tRNA合成酶抑制剂,IC50为0.20μM。GSK3036656可用于结核研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Li X, et, al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026.

GSK3036656物理化学性质

• 分子式: C₁₀H₁₃BClNO₄
• 分子量: 257.48

GSK3036656靶点实验

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实验名称：Half life in C57BL/6 mouse at 5.5 mg/kg, iv qd measured for 0.083 to 24 hrs post dose... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105134

实验名称：AUC (0 to infinity) in C57BL/6 mouse at 5.5 mg/kg, iv qd measured for 0.083 to 24 hrs... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105135

实验名称：Dose normalized AUC (0 to infinity) in C57BL/6 mouse at 5.5 mg/kg, iv qd measured for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105136

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis infected in mouse 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5127477

实验名称：Antibacterial activity against Mycobacterium tuberculosis H37Rv infected in C57BL/6J ... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5105131

实验名称：Volume of distribution at steady state in C57BL/6 mouse at 5.5 mg/kg, iv qd measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105132

实验名称：Clearance in C57BL/6 mouse at 5.5 mg/kg, iv qd measured for 0.083 to 24 hrs post dose... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105133

实验名称：Bioavailability in C57BL/6 mouse at 30 mg/kg, po qd via gavage measured for 0.25 to 2... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105142

实验名称：Tmax in C57BL/6 mouse at 30 mg/kg, po qd via gavage measured for 0.25 to 24 hrs post ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105138

实验名称：Half life in C57BL/6 mouse at 30 mg/kg, po qd via gavage measured for 0.25 to 24 hrs ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5105139

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