SH-42

• 常用名: SH-42
• 英文名: SH-42
• CAS号: 2143952-36-5
• 分子量: 402.57
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₈O₄
• 熔点: N/A
• 闪点: N/A

SH-42用途

SH-42是人类Δ24脱氢胆固醇还原酶(DHCR24)的有效和选择性抑制剂,IC50为42 nM。SH-42可导致小鼠血浆桥甾醇水平显著升高【1】。

SH-42名称

• 英文名: SH-42

SH-42生物活性

• 描述: SH-42是人类Δ24脱氢胆固醇还原酶(DHCR24)的有效和选择性抑制剂,IC50为42 nM。SH-42可导致小鼠血浆桥甾醇水平显著升高【1】。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 42 nM (DHCR24)[1]

• 参考文献:

  [1]. Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.

SH-42物理化学性质

• 分子式: C₂₅H₃₈O₄
• 分子量: 402.57

SH-42靶点实验

查看更多实验

实验名称：Inhibition of DHCR24-mediated cholesterol biosynthesis in human HL60 cells assessed a... 来源：ChEMBL 靶标：Delta(24)-sterol reductase External Id：CHEMBL4134393

实验名称：Inhibition of DHCR24 in human HL60 cells assessed as compound level causing induction... 来源：ChEMBL 靶标：Delta(24)-sterol reductase External Id：CHEMBL4134391

实验名称：Drug metabolism in human HL60 cells at 10 uM incubated for 24 hrs by GC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4134402

实验名称：Induction of sterol accumulation in human HL60 cells assessed as desmosterol accumula... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4134385

实验名称：Reduction in cholesterol level in C57BL/6 mouse blood at 500 ug/day, iv dosed daily f... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4134398

实验名称：Induction of desmosterol accumulation in C57BL/6 mouse blood at 500 ug/day, iv dosed ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4134399

实验名称：Liver toxicity in C57BL/6 mouse assessed as effect on AST levels at 500 ug/day, iv do... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4134396

实验名称：Induction of sterol accumulation in human HL60 cells assessed as desmosterol accumula... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4134380

实验名称：Acute liver toxicity in C57BL/6 mouse at 500 ug/day, iv dosed daily for 5 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4134397

实验名称：Cytotoxicity in human HL60 cells by MTT assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4134379

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