(+)-丁香树脂酚

• 常用名: (+)-丁香树脂酚
• 英文名: (+)-syringaresinol
• CAS号: 21453-69-0
• 分子量: 418.437
• 密度: 1.3±0.1 g/cm3
• 沸点: 594.7±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₆O₈
• 熔点: N/A
• 闪点: 313.5±30.1 °C

(+)-丁香树脂酚用途

(+)-丁香树脂醇,木脂素,是NFAT转录因子抑制剂,IC50为329.4μM.(+)-丁香树脂醇也可用于淋巴细胞白血病的研究[1][2]。

(+)-丁香树脂酚名称

• 中文名: (+)-丁香树脂酚
• 英文名: (+)-syringaresinol

(+)-丁香树脂酚生物活性

• 描述: (+)-丁香树脂醇,木脂素,是NFAT转录因子抑制剂,IC50为329.4μM.(+)-丁香树脂醇也可用于淋巴细胞白血病的研究[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 329.4 μM (NFAT transcription factor)[1]

• 体外研究: (+)-丁香树脂醇抑制P-388细胞的生长,ED50为0.41μg/mL[1]。
• 参考文献:

  [1]. Cai XF, et, al. Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum. Arch Pharm Res. 2004 Jul;27(7):738-41.

  [2]. Badawi MM, et, al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). J Pharm Sci. 1983 Nov;72(11):1285-7.

(+)-丁香树脂酚物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 594.7±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₆O₈
• 分子量: 418.437
• 闪点: 313.5±30.1 °C
• 精确质量: 418.162781
• PSA: 95.84000
• LogP: 0.71
• InChIKey: KOWMJRJXZMEZLD-HCIHMXRSSA-N
• SMILES: COc1cc(C2OCC3C(c4cc(OC)c(O)c(OC)c4)OCC23)cc(OC)c1O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.578
• 储存条件: 室温

(+)-丁香树脂酚靶点实验

查看更多实验

实验名称：Upregulation of PGC1-alpha protein expression in PPARbeta siRNA transfected mouse C2C... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830486

实验名称：Upregulation of CPT1 protein expression in PPARbeta siRNA transfected mouse C2C12 myo... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830488

实验名称：Induction of mitochondrial biogenesis in mouse C2C12 myotubes assessed as increase in... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830482

实验名称：Induction of mitochondrial biogenesis in mouse C2C12 myotubes assessed as increase in... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830483

实验名称：Upregulation of PPARbeta protein expression in PPARbeta siRNA transfected mouse C2C12... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830484

实验名称：Induction of SIRT1 protein expression in mouse C2C12 myotubes at 50 uM after 24 hrs b... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830603

实验名称：Activation of AMPK in mouse C2C12 myotubes assessed as increase in expression of phos... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3830604

实验名称：Upregulation of UCP2 protein expression in PPARbeta siRNA transfected mouse C2C12 myo... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830490

实验名称：Induction of mitochondrial DNA content in PPARbeta siRNA transfected mouse C2C12 myot... 来源：ChEMBL 靶标：C2C12 External Id：CHEMBL3830600

实验名称：Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL928450

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(+)-丁香树脂酚英文别名

• syringaresinol
• (+)-(7S,7'S,8R,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignane
• 4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol)
• (-) Syringaresinol
• (+)-lirioresinol B
• (+/-)-syringaresinol
• 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenyl]