AS2717638

• 常用名: AS2717638
• 英文名: AS2717638
• CAS号: 2148339-28-8
• 分子量: 447.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₅N₃O₅
• 熔点: N/A
• 闪点: N/A

AS2717638用途

AS2717638 是一种具有口服生物活性的,啮齿动物中 溶血磷脂酸受体5 (LPA5) 的拮抗剂。AS2717638 还能增强PGE2、PGF2α以及AMPA 诱导的异位疼痛。

AS2717638名称

• 中文名: AS2717638
• 英文名: AS2717638

AS2717638生物活性

• 描述: AS2717638 是一种具有口服生物活性的,啮齿动物中 溶血磷脂酸受体5 (LPA5) 的拮抗剂。AS2717638 还能增强PGE2、PGF2α以及AMPA 诱导的异位疼痛。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  LPA5[1].

• 参考文献:

  [1]. Murai N, et al. Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents. Neuropharmacology. 2017 Nov;126:97-107.

AS2717638物理化学性质

• 分子式: C₂₅H₂₅N₃O₅
• 分子量: 447.48
• InChIKey: QRMYHYZQUGJBBX-UHFFFAOYSA-N
• SMILES: COc1cc2c(C(=O)N3CCCCC3)cn(-c3noc4ccc(C)cc34)c(=O)c2cc1OC
• 储存条件: 2-8℃

AS2717638靶点实验

查看更多实验

实验名称：Antagonist activity at human LPA5 receptor expressed in RH7777 cells assessed as inhi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL5354229

实验名称：Antiallodynic activity against CFA-induced mechanical allodynia Sprague-Dawley rat mo... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5354245

实验名称：Antinociceptive activity in CCI surgery-neuropathic pain induced Sprague-Dawley rat m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5354246

实验名称：Antiallodynic activity against CFA-induced mechanical allodynia Sprague-Dawley rat mo... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5354243

实验名称：Selectivity ratio of IC50 for antagonist activity at human LPA5 receptor expressed in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5354227

实验名称：Antagonist activity at human LPA5 receptor expressed in RH7777 cells assessed as inhi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL5354228

实验名称：Antinociceptive activity in CCI surgery-neuropathic pain induced Sprague-Dawley rat m... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5354244

实验名称：Antagonist activity at human LPA5 receptor expressed in RH7777 cells assessed as inhi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL5354225

实验名称：Antagonist activity at human LPA5 receptor expressed in RH7777 cells assessed as inhi... 来源：ChEMBL 靶标：Lysophosphatidic acid receptor 5 External Id：CHEMBL5354226

实验名称：Antiallodynic activity against CFA-induced Sprague-Dawley rat inflammatory pain model... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL5354242

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