MurA-IN-2

• 常用名: MurA-IN-2
• 英文名: MurA-IN-2
• CAS号: 2164447-18-9
• 分子量: 229.75
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₂₀ClNO
• 熔点: N/A
• 闪点: N/A

MurA-IN-2用途

MurA-IN-2(化合物37)是一种含有初级脂肪胺的氯乙酰胺片段,是一种有效的MurA抑制剂,IC50值为39 微米。MurA-IN-2具有抗菌活性并抑制细菌细胞壁的合成[1]。

MurA-IN-2名称

• 英文名: MurA-IN-2

MurA-IN-2生物活性

• 描述: MurA-IN-2(化合物37)是一种含有初级脂肪胺的氯乙酰胺片段,是一种有效的MurA抑制剂,IC50值为39 微米。MurA-IN-2具有抗菌活性并抑制细菌细胞壁的合成[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 39 μM (MurA)[1]

• 体外研究: MurA-IN-2(化合物37；128μg/mL)抑制金黄色葡萄球菌ATCC29213和大肠杆菌ATCC25922的活性[1]。
• 参考文献:

  [1]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752.

  [2]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752.

MurA-IN-2物理化学性质

• 分子式: C₁₂H₂₀ClNO
• 分子量: 229.75

MurA-IN-2靶点实验

查看更多实验

实验名称：Irreversible inhibition of recombinant Escherichia coli MurA expressed in Escherichia... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354262

实验名称：Thiol reactivity of compound at pH 7.4 buffer at 100 uM and measured for 4 hrs every ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5354259

实验名称：Inhibition of recombinant Escherichia coli MurA expressed in Escherichia coli NiCo21 ... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354260

实验名称：Inhibition of recombinant Escherichia coli MurA expressed in Escherichia coli NiCo21 ... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354257

实验名称：Thiol reactivity of compound at pH 7.4 buffer assessed as fold decrease by measuring ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5354258

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5354269

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial grow... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5354270

实验名称：Irreversible inhibition of recombinant Escherichia coli MurA expressed in Escherichia... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354265

实验名称：Binding affinity to UNAG activated recombinant Escherichia coli MurA Cys115 residue a... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354266

实验名称：Irreversible inhibition of recombinant Escherichia coli MurA expressed in Escherichia... 来源：ChEMBL 靶标：UDP-N-acetylglucosamine 1-carboxyvinyltransferase External Id：CHEMBL5354264

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