EphA2 agonist 2

• 常用名: EphA2 agonist 2
• 英文名: EphA2 agonist 2
• CAS号: 2169273-66-7
• 分子量: 772.94
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₀H₅₆N₁₀O₆
• 熔点: N/A
• 闪点: N/A

EphA2 agonist 2用途

EphA2激动剂2(先导化合物)是一种具有抗肿瘤活性的选择性EphA2激动剂。EphA2激动剂2可穿过BBB【1】。

EphA2 agonist 2名称

• 英文名: EphA2 agonist 2

EphA2 agonist 2生物活性

• 描述: EphA2激动剂2(先导化合物)是一种具有抗肿瘤活性的选择性EphA2激动剂。EphA2激动剂2可穿过BBB【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> 艾弗林受体
• 体外研究: EphA2激动剂2(先导化合物)对U251 EphA2过度表达细胞和U251野生型细胞显示抗增殖活性,IC50值分别为2.1±1.05μM和5.2±2.56μM【1】。
• 参考文献:

  [1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

EphA2 agonist 2物理化学性质

• 分子式: C₄₀H₅₆N₁₀O₆
• 分子量: 772.94

EphA2 agonist 2靶点实验

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实验名称：Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as ... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4729690

实验名称：Anticlonogenic activity against human MDA-MB-231 cells up to 10 uM after 14 days by c... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4141784

实验名称：Agonist activity against EphA2 (unknown origin) overexpressed in MDA-MB-231-A2 cells ... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL4141781

实验名称：Binding affinity to EphA2 in human MDA-MB-231 cells assessed as induction of EphA2 re... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL4141782

实验名称：1-Octanol/water partition coefficient, log P of the compound incubated for 48 hrs by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729693

实验名称：Agonist activity at EPHA2 receptor (unknown origin) transfected in human U251 cells a... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL4729694

实验名称：Agonist activity against EphA2 (unknown origin) overexpressed in MDA-MB-231-A2 cells ... 来源：ChEMBL 靶标：Ephrin type-A receptor 2 External Id：CHEMBL4141780

实验名称：Antiproliferative activity against wild-type human U251 cells assessed as reduction i... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4729691

实验名称：Selectivity index, ratio of IC50 for wild-type human U251 cells to IC50 for human U25... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729692

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