Cjoc42

• 常用名: Cjoc42
• 英文名: Cjoc42
• CAS号: 2171519-89-2
• 分子量: 415.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁N₃O₅S
• 熔点: N/A
• 闪点: N/A

Cjoc42用途

Cjoc42是一种能够结合甘氨酸的化合物。Cjoc42以剂量依赖性方式抑制甘氨酸激酶活性。Cjoc42可防止通常与大量甘氨酸激酶相关的p53蛋白水平下降。Cjoc42恢复p53依赖的转录和对DNA损伤的敏感性【1】。

Cjoc42名称

• 英文名: Cjoc42

Cjoc42生物活性

• 描述: Cjoc42是一种能够结合甘氨酸的化合物。Cjoc42以剂量依赖性方式抑制甘氨酸激酶活性。Cjoc42可防止通常与大量甘氨酸激酶相关的p53蛋白水平下降。Cjoc42恢复p53依赖的转录和对DNA损伤的敏感性【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> MDM-2/p53
• 参考文献:

  [1]. Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732.

Cjoc42物理化学性质

• 分子式: C₂₀H₂₁N₃O₅S
• 分子量: 415.46

Cjoc42靶点实验

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实验名称：Binding affinity to gankyrin (unknown origin) assessed as fold increase in change in ... 来源：ChEMBL 靶标：26S proteasome non-ATPase regulatory subunit 10 External Id：CHEMBL4611527

实验名称：Antiproliferative activity against human HepG2 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4611531

实验名称：Antiproliferative activity against human Hep3B cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL4611530

实验名称：Antiproliferative activity against human HuH-6 cells incubated for 72 hrs by MTT assa... 来源：ChEMBL 靶标：HuH-6 External Id：CHEMBL5577910

实验名称：Binding affinity to recombinant human His-tagged gankyrin expressed in Escherichia co... 来源：ChEMBL 靶标：26S proteasome non-ATPase regulatory subunit 10 External Id：CHEMBL4821989

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inh... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL5124947

实验名称：Cytotoxicity against human A549 cells assessed as reduction in cell viability incubat... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4727337

实验名称：Antiproliferative activity against human A549 cells assessed as cell growth inhibitio... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5124948

实验名称：Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability i... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4727338

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