Paltusotine

• 常用名: Paltusotine
• 英文名: Paltusotine
• CAS号: 2172870-89-0
• 分子量: 456.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₂F₂N₄O
• 熔点: N/A
• 闪点: N/A

Paltusotine用途

帕托司汀(CRN00808)是一种口服活性、非肽选择性生长抑素2型(SST2)受体激动剂。帕图索汀有可能在生长抑素受体配体治疗后维持GH和IGF-1水平[1][2]。

Paltusotine名称

• 英文名: Paltusotine

Paltusotine生物活性

• 描述: 帕托司汀(CRN00808)是一种口服活性、非肽选择性生长抑素2型(SST2)受体激动剂。帕图索汀有可能在生长抑素受体配体治疗后维持GH和IGF-1水平[1][2]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体
  研究领域 >> 内分泌
• 参考文献:

  [1]. Murray B. Gordon, et al. Identification of a dose range for once daily oral paltusotine in patients with acromegaly that maintains IGF-1 levels when switching from long-acting somatostatin receptor ligand therapy. Endocrine Abstracts (2021) 73 OC15.4.

  [2]. Rosa Luo, et al. Pharmacokinetics and Safety of an Improved Oral Formulation of Paltusotine, a Selective, Non-Peptide Somatostatin Receptor 2 (SST2) Agonist for the Treatment of Acromegaly. Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021.

Paltusotine物理化学性质

• 分子式: C₂₇H₂₂F₂N₄O
• 分子量: 456.49

Paltusotine靶点实验

查看更多实验

实验名称：Inhibition of human CYP2C19 expressed in insect cell microsomes at 10 uM in presence ... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL5225684

实验名称：Inhibition of human CYP2C9 expressed in insect cell microsomes at 10 uM in presence o... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL5225683

实验名称：Half life in rat liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225677

实验名称：Selectivity index, ratio of pEC50 for agonist activity at human SST5 receptor express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225674

实验名称：Selectivity index, ratio of pEC50 for agonist activity at human SST4 receptor express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225673

实验名称：Half life in human liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225676

实验名称：Agonist activity at human SST4 receptor expressed in CHO-K1 cells assessed as inhibit... 来源：ChEMBL 靶标：Somatostatin receptor type 4 External Id：CHEMBL5225669

实验名称：Selectivity index, ratio of pEC50 for agonist activity at human SST3 receptor express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225672

实验名称：Selectivity index, ratio of pEC50 for agonist activity at human SST1 receptor express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225671

实验名称：Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibit... 来源：ChEMBL 靶标：Somatostatin receptor type 2 External Id：CHEMBL5225666

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